Fluorescent activatable gadofullerene nanoprobes as NIR-MR dual-modal in vivo imaging contrast agent
文献类型：期刊论文
| 作者 | Sun, Baoyun ; Li C(李成); Huang H(黄换); Cui RL(崔荣丽); Li J(李娟); Guo XH(郭喜红); Yao HL(要换丽); Liu B(刘兵); Xu BG(徐秉刚); Li Y(李颖)
|
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2018 |
| 卷号 | 171页码:159-166 |
| 关键词 | Gadofullerene nanoprobes Fluorescent activatable MRI Dual Imaging agents |
| ISSN号 | 0927-7765 |
| DOI | 10.1016/j.colsurfb.2018.07.026 |
| 文献子类 | Article |
| 英文摘要 | Dual mode imaging technology is widely developed to achieve the early-stage precision cancer diagnosis. Here we designed a dual-modal magnetic resonance/near infrared fluorescence optical imaging contrast agent (GdF-SS-NIR783) with the fluorescence activatable and safer gadofullerene. The nanoprobes were fabricated by conjugating the gadofullerene derivatives with a NIR fluorescence imaging agent (NIR783) via the disulfide bond. The obtained nanoprobes showed no fluorescence (OFF), but the fluorescence turned on when incubated within reduction environment such as GSH solution. The clear fluorescence signal in tumor site was observed obviously after their intraturnor injection. The nanoprobes also revealed efficient MRI contrast enhancement both in Vitra and in vivo. And they showed good biocompatibility and did not demonstrate any tissue toxicity in vivo. This work gave the new possibility in designing more efficient and safer nanoprobes for future medical diagnoses, |
| 电子版国际标准刊号 | 1873-4367 |
| WOS关键词 | MAGNETIC-RESONANCE ; NANOPARTICLES ; NANOCOMPOSITE ; GD-AT-C-2V(9)-C-82 ; METALLOFULLERENE ; METAL |
| WOS研究方向 | Biophysics ; Chemistry ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000447575400020 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286605]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 通讯作者 | Sun BY(孙宝云) |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Sun, Baoyun,Li C,Huang H,et al. Fluorescent activatable gadofullerene nanoprobes as NIR-MR dual-modal in vivo imaging contrast agent[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2018,171:159-166. |
| APA | Sun, Baoyun.,李成.,黄换.,崔荣丽.,李娟.,...&Xing, Gengmei.(2018).Fluorescent activatable gadofullerene nanoprobes as NIR-MR dual-modal in vivo imaging contrast agent.COLLOIDS AND SURFACES B-BIOINTERFACES,171,159-166. |
| MLA | Sun, Baoyun,et al."Fluorescent activatable gadofullerene nanoprobes as NIR-MR dual-modal in vivo imaging contrast agent".COLLOIDS AND SURFACES B-BIOINTERFACES 171(2018):159-166. |
入库方式： OAI收割
来源：高能物理研究所
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