Altered regional and circuit resting-state activity in patients with occult spastic diplegic cerebral palsy
文献类型：期刊论文
| 作者 | Duan SF(段绍峰) ; Dan BC(单保慈); Nie, Binbin; Duan, Shaofeng; Ma, Qiaozhi; Dai, Guanghui; Wu, Chunnan; Dong, Yuru; Shan, Baoci; Ma, Lin
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| 刊名 | PEDIATRICS & NEONATOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 59期号:4页码:345-351 |
| 关键词 | cerebral palsy functional connectivity magnetic resonance imaging regional homogeneity resting-state functional magnetic resonance imaging |
| ISSN号 | 1875-9572 |
| DOI | 10.1016/j.pedneo.2017.10.003 |
| 文献子类 | Article |
| 英文摘要 | Background: Very few studies have been made to investigate functional activity changes in occult spastic diplegic cerebral palsy (SDCP). The purpose of this study was to analyze whole-brain resting state regional brain activity and functional connectivity (FC) changes in patients with SDCP. Methods: We examined 12 occult SDCP and 14 healthy control subjects using resting-state functional magnetic resonance imaging. The data were analyzed using Resting-State fMRI Data Analysis Toolkit (REST) software. The regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and whole brain FC of the motor cortex and thalamus were analyzed and compared between the occult SDCP and control groups. Results: Compared with the control group, the occult SDCP group showed decreased ReHo regions, including the bilateral frontal, parietal, and temporal lobes, the cerebellum, right cingulate gyrus, and right lenticular nucleus, whereas an increased ReHo value was observed in the left precuneus, calcarine, fusiform gyrus, and right precuneus. Compared with the control group, no significant differences in ALFF were noted in the occult SDCP group. With the motor cortex as the region of interest, the occult SDCP group showed decreased connectivity regions in the bilateral fusiform and lingual gyrus, but increased connectivity regions in the contralateral precentral and postcentral gyrus, supplementary motor area, and the ipsilateral postcentral gyrus. With the thalamus being regarded as the region of interest, the occult SDCP group showed decreased connectivity regions in the bilateral basal ganglia, cingulate, and prefrontal cortex, but increased connectivity regions in the bilateral precentral gyrus, the contralateral cerebellum, and inferior temporal gyrus. Conclusions: Resting-state regional brain activities and FC changes in the patients with occult SDCP exhibited a special distribution pattern, which is consistent with the pathology of the disease. Copyright (C) 2017, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. |
| 电子版国际标准刊号 | 2212-1692 |
| WOS关键词 | BRAIN ACTIVITY ; PERIVENTRICULAR LEUKOMALACIA ; FUNCTIONAL CONNECTIVITY ; CHILDREN ; CLASSIFICATION ; DEFINITION ; DEFICITS ; INJURY ; DAMAGE |
| WOS研究方向 | Chemistry ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000454041700004 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286700]  |
| 专题 | 高能物理研究所_核技术应用研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Duan SF,Dan BC,Nie, Binbin,et al. Altered regional and circuit resting-state activity in patients with occult spastic diplegic cerebral palsy[J]. PEDIATRICS & NEONATOLOGY,2018,59(4):345-351. |
| APA | 段绍峰.,单保慈.,Nie, Binbin.,Duan, Shaofeng.,Ma, Qiaozhi.,...&Mu, Xuetao.(2018).Altered regional and circuit resting-state activity in patients with occult spastic diplegic cerebral palsy.PEDIATRICS & NEONATOLOGY,59(4),345-351. |
| MLA | 段绍峰,et al."Altered regional and circuit resting-state activity in patients with occult spastic diplegic cerebral palsy".PEDIATRICS & NEONATOLOGY 59.4(2018):345-351. |
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来源：高能物理研究所
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