Interaction between Surface Charge-Modified Gold Nanoparticles and Phospholipid Membranes
文献类型：期刊论文
| 作者 | Yao, L; Wang, JY ; Zhao, XY; Ma, WS; Wu ZH(吴忠华); Yao L(姚磊); Xing XQ(邢雪青); Xing, XQ; Zhao XY(赵晓艺); Wang JY(王佳怡)
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| 刊名 | LANGMUIR
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| 出版日期 | 2018 |
| 卷号 | 34期号:42页码:12583-12589 |
| ISSN号 | 0743-7463 |
| DOI | 10.1021/acs.langmuir.8b01700 |
| 文献子类 | Article |
| 英文摘要 | This report clarifies the interaction of surface charge-modified gold nanoparticles (AuNPs) with phospholipid membranes, which is helpful to understand the antibacterial mechanism of positive charge-modified AuNPs to Gram-negative bacteria. Although the simulated bacterial cell membranes as a whole are negatively charged, the local electrostatic repulsive interaction between the positive charge-coated AuNPs and the small-sized flexible cationic head group of dioleyl phosphatidylethanolamine molecules induces the phase transformation of the simulated bacterial cell membranes from a lamellar to an inverted hexagonal phase. Transmembrane pores with a diameter of about 3.0 nm in the inverted hexagonal structure would result in the destruction of cell membrane function. Such an interaction of positive charge-modified AuNPs with the membrane mimics provides a promising route to develop new antibacterial agents by modifying positive charges on the surface of nanoparticles. |
| WOS关键词 | X-RAY-DIFFRACTION ; MODEL CELL-MEMBRANES ; INVERTED HEXAGONAL PHASE ; GRAM-NEGATIVE BACTERIA ; SILVER NANOPARTICLES ; LIPID-BILAYERS ; HII PHASE ; CURVATURE ; MECHANISM ; TRANSITIONS |
| WOS研究方向 | Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000448752700008 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286707]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 高能物理研究所_加速器中心 |
| 通讯作者 | Wu ZH(吴忠华) |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Yao, L,Wang, JY,Zhao, XY,et al. Interaction between Surface Charge-Modified Gold Nanoparticles and Phospholipid Membranes[J]. LANGMUIR,2018,34(42):12583-12589. |
| APA | Yao, L.,Wang, JY.,Zhao, XY.,Ma, WS.,吴忠华.,...&Jiang, XY.(2018).Interaction between Surface Charge-Modified Gold Nanoparticles and Phospholipid Membranes.LANGMUIR,34(42),12583-12589. |
| MLA | Yao, L,et al."Interaction between Surface Charge-Modified Gold Nanoparticles and Phospholipid Membranes".LANGMUIR 34.42(2018):12583-12589. |
入库方式： OAI收割
来源：高能物理研究所
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