Functionalized MoS2 Nanovehicle with Near-Infrared Laser-Mediated Nitric Oxide Release and Photothermal Activities for Advanced Bacteria-Infected Wound Therapy
文献类型：期刊论文
| 作者 | Zhao YL(赵宇亮) ; Gao Q(高琴); Zhang X(张潇); Yin WY(尹文艳); Ma DQ(马冬青); Xie CJ(谢昌健); Zheng LR(郑黎荣); Dong XH(董兴华); Mei LQ(梅林强); Yu J(余杰)
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| 刊名 | SMALL
 |
| 出版日期 | 2018 |
| 卷号 | 14期号:45页码:1802290 |
| 关键词 | hyperthermia light-mediated synergetic therapy MoS2 wound disinfection and healing |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201802290 |
| 文献子类 | Article |
| 英文摘要 | The rising dangers of bacterial infections have created an urgent need for the development of a new generation of antibacterial nanoagents and therapeutics. A new near-infrared 808 nm laser-mediated nitric oxide (NO)-releasing nanovehicle (MoS2-BNN6) is reported through the simple assembly of alpha-cyclodextrin-modified MoS2 nanosheets with a heat-sensitive NO donor N,N '-di-sec-butyl-N,N '-dinitroso-1,4-phenylenediamine (BNN6) for the rapid and effective treatment of three typical Gram-negative and Gram-positive bacteria (ampicillin-resistant Escherichia coli, heat-resistant Escherichia faecalis, and pathogen Staphylococcus aureus). This MoS2-BNN6 nanovehicle has good biocompatibility and can be captured by bacteria to increase opportunities of NO diffusion to the bacterial surface. Once stimulated by 808 nm laser irradiation, the MoS2-BNN6 nanovehicle not only exhibits photothermal therapy (PTT) efficacy but also can precisely control NO release, generating oxidative/nitrosative stress. The temperature-enhanced catalytic function of MoS2 induced by 808 nm laser irradiation simultaneously accelerates the oxidation of glutathione. This acceleration disrupts the balance of antioxidants, ultimately resulting in significant DNA damage to the bacteria. Within 10 min, the MoS2-BNN6 with enhanced PTT/NO synergetic antibacterial function achieves >97.2% inactivation of bacteria. The safe synergetic therapy strategy can also effectively repair wounds through the formation of collagen fibers and elimination of inflammation during tissue reconstruction. |
| 电子版国际标准刊号 | 1613-6829 |
| WOS关键词 | CHEMICALLY EXFOLIATED MOS2 ; ANTIBACTERIAL ACTIVITY ; SILVER NANOPARTICLES ; ESCHERICHIA-COLI ; CANCER-THERAPY ; QUANTUM DOTS ; COMET ASSAY ; GRAPHENE ; RESISTANCE ; NANOSHEETS |
| WOS研究方向 | Environmental Sciences & Ecology ; Meteorology & Atmospheric Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000449542800019 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286850]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhao YL,Gao Q,Zhang X,et al. Functionalized MoS2 Nanovehicle with Near-Infrared Laser-Mediated Nitric Oxide Release and Photothermal Activities for Advanced Bacteria-Infected Wound Therapy[J]. SMALL,2018,14(45):1802290. |
| APA | 赵宇亮.,高琴.,张潇.,尹文艳.,马冬青.,...&Zhao, Yuliang.(2018).Functionalized MoS2 Nanovehicle with Near-Infrared Laser-Mediated Nitric Oxide Release and Photothermal Activities for Advanced Bacteria-Infected Wound Therapy.SMALL,14(45),1802290. |
| MLA | 赵宇亮,et al."Functionalized MoS2 Nanovehicle with Near-Infrared Laser-Mediated Nitric Oxide Release and Photothermal Activities for Advanced Bacteria-Infected Wound Therapy".SMALL 14.45(2018):1802290. |
入库方式： OAI收割
来源：高能物理研究所
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