Near-Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin
文献类型：期刊论文
| 作者 | Wen, Kaikai; Wen KK(温凯凯); Zhou MX(周梦雪); Lu HR(卢会茹); Bi Y(毕颖); Ruan LF(阮利佛); Chen J(陈俊) ; Hu Y(胡毅); Zhou, Mengxue; Lu, Huiru
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| 刊名 | ACS BIOMATERIALS SCIENCE & ENGINEERING
 |
| 出版日期 | 2018 |
| 卷号 | 4期号:12页码:4244-4254 |
| 关键词 | near-infrared poly(beta-amino ester) upconversion nanoparticles intracellular drug delivery mitochondrion |
| ISSN号 | 2373-9878 |
| DOI | 10.1021/acsbiomaterials.8b01051 |
| 文献子类 | Article |
| 英文摘要 | Herein, we designed near-infrared (NIR)/pH dual-sensitive nanocarriers and evaluated its application to intracellular drug delivery. The nanocarriers were prepared based on amphiphilic poly(beta-amino ester) (PBAE) containing o-nitrobenzyl moieties in the backbones and upconversion nano particles (UCNPs). UCNPs can convert NIR to UV that subsequently removes PEG segments from PBAE copolymers, which could enhance the protonation of PBAE in endo/lysosomes and facilitate the escape of the nanoparticles from lysosomes. In addition, we found the colocalization of the nanoparticles with mitochondria inside the cells, presumably resulting from high hydrophobicity and positive charges of the nanoparticles. The results showed that the nanocarriers with the aid of NIR could enhance the intracellular delivery of DOX, as compared with free DOX and NIR-free control. Furthermore PBAE@UCNPs-DOX with NIR potently inhibited tumor growth in mice. Therefore, the intelligent micellar nanoparticles might provide a simple yet effective nanoplatform to achieve mitochondrion-targeting drug delivery. |
| WOS关键词 | ANTICANCER DRUG-DELIVERY ; ENERGY-TRANSFER ; NANOPARTICLES ; MITOCHONDRIA |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000453109000033 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286872]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Wen, Kaikai,Wen KK,Zhou MX,et al. Near-Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2018,4(12):4244-4254. |
| APA | Wen, Kaikai.,温凯凯.,周梦雪.,卢会茹.,毕颖.,...&Hu, Yi.(2018).Near-Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin.ACS BIOMATERIALS SCIENCE & ENGINEERING,4(12),4244-4254. |
| MLA | Wen, Kaikai,et al."Near-Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin".ACS BIOMATERIALS SCIENCE & ENGINEERING 4.12(2018):4244-4254. |
入库方式： OAI收割
来源：高能物理研究所
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