Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca2+ Bundles
文献类型：期刊论文
| 作者 | Qin YX(秦艳霞); Bai X(白雪); Chang YN(常亚男) ; Gu, Weihong; Chen, Kui; Zhao, Xiaoyi; Geng, Huan; Li, Juan; Qin, Yanxia; Bai, Xue
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| 刊名 | SMALL
 |
| 出版日期 | 2018 |
| 卷号 | 14期号:48页码:1802549 |
| 关键词 | actin fullerenol osteoporosis ruffled borders synchrotron radiation small angle X-ray scattering (SAXS) |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201802549 |
| 文献子类 | Article |
| 英文摘要 | Osteoporosis, a common and serious bone disorder affecting aged people and postmenopausal women, is characterized by osteoclast overactivity. One therapeutic strategy is suppressing the bone resorption function of hyperactive osteoclasts, but there is no effective drug in clinical practice so far. Herein, it is demonstrated that fullerenols suppress the bone resorption of osteoclasts by inhibiting ruffled borders (RBs) formation. The RBs formation, which is supported by well-aligned actin bundles (B-actins), is a critical event for osteoclast bone resorption. To facilitate this function, osteoclast RBs dynamics is regulated by variable microenvironments to bundle F-actins, protrude cell membrane, and so on. B-actin perturbation by fullerenols is determined here, offering an opportunity to regulate osteoclast function by destroying RBs. In vivo, the therapeutic effect of fullerenols on overactive osteoclasts is confirmed in a mouse model of lipopolysaccharide-induced bone erosion. Collectively, the findings suggest that fullerenols adhere to F-actin surfaces and inhibit RBs formation in osteoclasts, mainly through hampering Ca2+ from bundling F-actins, and this is likely due to the stereo-hindrance effect caused by adherent fullerenols. |
| 电子版国际标准刊号 | 1613-6829 |
| WOS关键词 | F-ACTIN ; CELLULAR UPTAKE ; IN-VITRO ; NANOPARTICLES ; CALCIUM ; ORGANIZATION ; POLYAMINES ; MECHANISM ; DIFFERENTIATION ; CYTOTOXICITY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000451566800009 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286897]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 通讯作者 | Xing GM(邢更妹) |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Qin YX,Bai X,Chang YN,et al. Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca2+ Bundles[J]. SMALL,2018,14(48):1802549. |
| APA | 秦艳霞.,白雪.,常亚男.,Gu, Weihong.,Chen, Kui.,...&李娟.(2018).Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca2+ Bundles.SMALL,14(48),1802549. |
| MLA | 秦艳霞,et al."Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca2+ Bundles".SMALL 14.48(2018):1802549. |
入库方式： OAI收割
来源：高能物理研究所
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