Advanced Nuclear and Related Techniques for Metallomics and Nanometallomics
文献类型：期刊论文
| 作者 | Li, Yu-Feng ; Chai, Zhifang; Chen, Chunying; Gao, Yuxi; Zhao, Jiating; Li YF(李玉锋); Zhao JT(赵甲亭); Gao YX(高愈希); Chai ZF(柴之芳)
|
| 刊名 | METALLOMICS: THE SCIENCE OF BIOMETALS
 |
| 出版日期 | 2018 |
| 页码 | 213-243 |
| 关键词 | Metallomics Nanometallomics Nuclear analytical techniques Metals Metal-related nanomaterials |
| ISSN号 | 0065-2598 |
| DOI | 10.1007/978-3-319-90143-5_9 |
| 文献子类 | Article; Book Chapter |
| 英文摘要 | Metallomics, focusing on the global and systematic understanding of the metal uptake, trafficking, role, and excretion in biological systems, has attracted more and more attention. Metal-related nanomaterials, including metallic and metal-containing nanomaterials, have unique properties compared to their macroscale counterparts and therefore require special attention. The absorption, distribution, metabolism, excretion (ADME) behavior of metal-related nanomaterials in the biological systems is influenced by their physicochemical properties, the exposure route, and the microenvironment of the deposition site. Nanomaterials not only may interact directly or indirectly with genes, proteins, and other molecules to bring genotoxicity, immunotoxicity, DNA damage, and cytotoxicity but may also stimulate the immune responses, circumvent tumor resistance, and inhibit tumor metastasis. Because of their advantages of absolute quantification, high sensitivity, excellent accuracy and precision, low matrix effects, and nondestructiveness, nuclear and related analytical techniques have been playing important roles in the study of metallomics and nanometallomics. In this chapter, we present a comprehensive overview of nuclear and related analytical techniques applied to the quantification of metallome and nanometallome, the biodistribution, bioaccumulation, and transformation of metallome and nanometallome in vivo, and the structural analysis. Besides, metallomics and nanometallomics need to cooperate with other -omics, like genomics, proteomics, and metabolomics, to obtain the knowledge of underlying mechanisms and therefore to improve the application performance and to reduce the potential risk of metallome and nanometallome. |
| 电子版国际标准刊号 | 2214-8019 |
| WOS关键词 | X-RAY-FLUORESCENCE ; PLASMA-MASS SPECTROMETRY ; ABLATION-ICP-MS ; MOLECULAR ACTIVATION-ANALYSIS ; INHALED ULTRAFINE PARTICLES ; INTEGRATED BIOMETAL SCIENCE ; PROTEIN SECONDARY STRUCTURE ; SEMICONDUCTOR QUANTUM DOTS ; RESOLVED TRACE ANALYSIS ; MICRO-XRF SPECTROMETER |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000448876600010 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286909]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 通讯作者 | Chai ZF(柴之芳) |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Li, Yu-Feng,Chai, Zhifang,Chen, Chunying,et al. Advanced Nuclear and Related Techniques for Metallomics and Nanometallomics[J]. METALLOMICS: THE SCIENCE OF BIOMETALS,2018:213-243. |
| APA | Li, Yu-Feng.,Chai, Zhifang.,Chen, Chunying.,Gao, Yuxi.,Zhao, Jiating.,...&柴之芳.(2018).Advanced Nuclear and Related Techniques for Metallomics and Nanometallomics.METALLOMICS: THE SCIENCE OF BIOMETALS,213-243. |
| MLA | Li, Yu-Feng,et al."Advanced Nuclear and Related Techniques for Metallomics and Nanometallomics".METALLOMICS: THE SCIENCE OF BIOMETALS (2018):213-243. |
入库方式： OAI收割
来源：高能物理研究所
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