A Conscious Resting State fMRI Study in SLE Patients Without Major Neuropsychiatric Manifestations
文献类型：期刊论文
| 作者 | Xu, L. ; Liu, S.; Cheng, Y.; Xie, Z.; Lai, A.; Lv, Z.; Zhao, Y.; Xu, X.; Luo, C.; Yu, H.
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| 刊名 | FRONTIERS IN PSYCHIATRY
 |
| 出版日期 | 2018 |
| 卷号 | 9页码:677 |
| 关键词 | systemic lupus erythematosus patients without major neuropsychiatric manifestations (non-NPSLE patients) resting-state functional magnetic resonance imaging (rs-fMRI) regional homogeneity (ReHo) disease activity anxiety depression |
| ISSN号 | 1664-0640 |
| DOI | 10.3389/fpsyt.2018.00677 |
| 文献子类 | Article |
| 英文摘要 | Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the main causes of death in patients with systemic lupus erythematosus (SLE). Signs and symptoms of NPSLE are heterogeneous, and it is hard to diagnose, and treat NPSLE patients in the early stage. We conducted this study to explore the possible brain activity changes using resting state functional magnetic resonance imaging (rs-fMRI) in SLE patients without major neuropsychiatric manifestations (non-NPSLE patients). We also tried to investigate the possible associations among brain activity, disease activity, depression, and anxiety. In our study, 118 non-NPSLE patients and 81 healthy controls (HC) were recruited. Rs-fMRI data were used to calculate the regional homogeneity (ReHo) in all participants. We found decreased ReHo values in the fusiform gyrus and thalamus and increased ReHo values in the parahippocampal gyrus and uncus. The disease activity was positively correlated with ReHo values of the cerebellum and negatively correlated with values in the frontal gyrus. Several brain areas showed correlations with depressive and anxiety statuses. These results suggested that abnormal brain activities might occur before NPSLE and might be the foundation of anxiety and depression symptoms. Early detection and proper treatment of brain dysfunction might prevent the progression to NPSLE. More studies are needed to understand the complicated underlying mechanisms. |
| WOS关键词 | SYSTEMIC-LUPUS-ERYTHEMATOSUS ; DISEASE-ACTIVITY INDEX ; SCALE BRAIN NETWORKS ; FUNCTIONAL CONNECTIVITY ; WORKING-MEMORY ; MRI ; HOMOGENEITY ; COGNITION |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000452540200001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286980]  |
| 专题 | 高能物理研究所_核技术应用研究中心 高能物理研究所_实验物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Xu, L.,Liu, S.,Cheng, Y.,et al. A Conscious Resting State fMRI Study in SLE Patients Without Major Neuropsychiatric Manifestations[J]. FRONTIERS IN PSYCHIATRY,2018,9:677. |
| APA | Xu, L..,Liu, S..,Cheng, Y..,Xie, Z..,Lai, A..,...&单保慈.(2018).A Conscious Resting State fMRI Study in SLE Patients Without Major Neuropsychiatric Manifestations.FRONTIERS IN PSYCHIATRY,9,677. |
| MLA | Xu, L.,et al."A Conscious Resting State fMRI Study in SLE Patients Without Major Neuropsychiatric Manifestations".FRONTIERS IN PSYCHIATRY 9(2018):677. |
入库方式： OAI收割
来源：高能物理研究所
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