帕金森病中的关键金属元素
文献类型：期刊论文
| 作者 | 黄辉; 陈俊 ; 卢会茹; 周梦雪; Chai, ZF; 胡毅; 柴之芳; Huang, H; Chen, J; Lu, HR
|
| 刊名 | 化学进展
 |
| 出版日期 | 2018 |
| 卷号 | 30期号:10页码:1592-1600 |
| 关键词 | Parkinson's disease iron copper oxidative stress synchrotron radiation |
| ISSN号 | 1005-281X |
| DOI | 10.7536/PC180609 |
| 其他题名 | Neurotoxicity of Key Metals in Parkinson s Disease |
| 文献子类 | Review |
| 英文摘要 | As China' s aging population continues to increase, it is estimated that people with Parkinson' s disease (PD) in China account for about half of PD cases in the world. Therefore, PD has become one of the fastest growing threats to public health in China. Currently, there is no cure for PD. The etiology and pathogenesis of PD remain elusive. Metal dyshomeostasis and oxidative stress are deemed as important risk factors for PD. Herein, recent advances in the neurotoxicity of key metals in PD are reviewed, and possible mechanisms underlying iron/copper-mediated neuron lesion are discussed. In addition, the application of synchrotron radiation in elemental analysis and mechanistic study of PD are briefly introduced. Lastly, the challenges and perspectives for bioinorganic chemistry in PD are discussed. |
| WOS关键词 | IRON-INDUCED GENERATION ; HUMAN SUBSTANTIA-NIGRA ; ALPHA-SYNUCLEIN ; ELEMENTAL COMPOSITION ; FLUORESCENT-PROBES ; COPPER TOXICITY ; CELL-DEATH ; IN-VIVO ; FERROPTOSIS ; BRAIN |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6402838 |
| WOS记录号 | WOS:000451113600013 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/286992]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 |
| 通讯作者 | 胡毅 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | 黄辉,陈俊,卢会茹,等. 帕金森病中的关键金属元素[J]. 化学进展,2018,30(10):1592-1600. |
| APA | 黄辉.,陈俊.,卢会茹.,周梦雪.,Chai, ZF.,...&Hu, Y.(2018).帕金森病中的关键金属元素.化学进展,30(10),1592-1600. |
| MLA | 黄辉,et al."帕金森病中的关键金属元素".化学进展 30.10(2018):1592-1600. |
入库方式： OAI收割
来源：高能物理研究所
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