Cerebral Responses to Acupuncture at GV24 and Bilateral GB13 in Rat Models of Alzheimer's Disease
文献类型：期刊论文
| 作者 | Wong, J; Shan, BC; Nie, BB ; Lai, XS; Wang, QM; Huang, JT; Xu, MZ; Cui, SY; Dan BC(单保慈); Nie BB(聂彬彬)
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| 刊名 | BEHAVIOURAL NEUROLOGY
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| 出版日期 | 2018 |
| 页码 | 8740284 |
| ISSN号 | 0953-4180 |
| DOI | 10.1155/2018/8740284 |
| 文献子类 | Article |
| 英文摘要 | Acupuncture has been widely used in China to treat neurological diseases including Alzheimer's disease (AD). However, its mechanism remains unclear. In the present study, eighty healthy Wistar rats were divided into a normal control group (n = 15) and premodel group (n = 65). Forty-five rats that met the criteria for the AD model were then randomly divided into the model group (MG), the nonacupoint group (NG), and the acupoint group (AG). All rats received positron emission tomography (PET) scanning, and the images were analyzed with Statistical Parametric Mapping 8.0. MG exhibited hypometabolism in the olfactory bulb, insular cortex, orbital cortex, prelimbic cortex, striatum, parietal association cortex, visual cortex, cingulate gyrus, and retrosplenial cortex. AG exhibited prominent and extensive hypermetabolism in the thalamus, hypothalamus, bed nucleus of the stria terminalis, cerebral peduncle, midbrain tegmentum, and pontine tegmentum compared to NG. These results demonstrated that acupuncturing at GV24 and bilateral GB13 acupoints may improve the learning and memory abilities of the AD rats, probably via altering cerebral glucose metabolism (CGM) in the hypothalamus, thalamus, and brain stem. The observed effects of acupuncture may be caused by regulating the distribution of certain kinds of neurotransmitters and enhancing synaptic plasticity. |
| 电子版国际标准刊号 | 1875-8584 |
| WOS关键词 | POSITRON-EMISSION-TOMOGRAPHY ; MILD COGNITIVE IMPAIRMENT ; DEEP BRAIN-STIMULATION ; GLUCOSE-METABOLISM ; MOUSE MODEL ; SYNAPTIC-TRANSMISSION ; OLFACTORY DYSFUNCTION ; STRIA TERMINALIS ; F-18-FDG PET ; BED NUCLEUS |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000432178200001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/287024]  |
| 专题 | 高能物理研究所_核技术应用研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Wong, J,Shan, BC,Nie, BB,et al. Cerebral Responses to Acupuncture at GV24 and Bilateral GB13 in Rat Models of Alzheimer's Disease[J]. BEHAVIOURAL NEUROLOGY,2018:8740284. |
| APA | Wong, J.,Shan, BC.,Nie, BB.,Lai, XS.,Wang, QM.,...&Luo, X.(2018).Cerebral Responses to Acupuncture at GV24 and Bilateral GB13 in Rat Models of Alzheimer's Disease.BEHAVIOURAL NEUROLOGY,8740284. |
| MLA | Wong, J,et al."Cerebral Responses to Acupuncture at GV24 and Bilateral GB13 in Rat Models of Alzheimer's Disease".BEHAVIOURAL NEUROLOGY (2018):8740284. |
入库方式： OAI收割
来源：高能物理研究所
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