Cerebral Glucose Metabolism Assessment in Rat Models of Alzheimer's Disease: An F-18-FDG-PET Study
文献类型：期刊论文
| 作者 | Huang, Y; Chen, JQ; Cui, SY; Ren, J; Lu, YJ; Nie, BB; Lai, XS; Dan BC(单保慈); Nie BB(聂彬彬); Shan, B |
| 刊名 | AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
 |
| 出版日期 | 2016 |
| 卷号 | 31期号:4页码:333-340 |
| ISSN号 | 1533-3175 |
| 关键词 | Alzheimer's disease rat model PET metabolism |
| DOI | 10.1177/1533317515617725 |
| 文献子类 | Article |
| 英文摘要 | Objective: This study was designed to detect the brain glucose metabolism in rat models of Alzheimer's disease (AD) by the application of F-18-2-fluoro-deoxy-d-glucose positron emission tomography (F-18-FDG-PET) and to provide new insights for the early detection of AD. Methods: Forty Wistar rats were randomly divided into 2 groups. Fifteen sham-operated rats were used as a control group. The remaining rats as a premodel group were intracerebroventricularly injected with ibotenic acid and were intraperitoneally injected with d-galactose, of which 15 rats were included as the experimental group. The above-mentioned 2 groups were assigned to Y-maze test and underwent F-18-FDG-PET scanning. Positron emission tomography images were processed with SPM 2.0. Results: The learning and memory skills were weakened in AD rats. Besides, the glucose metabolic activity of AD rats decreased in hippolampus, hypothalamus, insular cortex, piriform cortex, striatum, cingulate gyrus, stria terminalis, and parietal lobe and increased in olfactory bulb, cerebellum, midbrain, pontine, and retrosplenial cortex compared with the control group. Dorsal thalamus had shown both enhanced and reduced glucose metabolic activity. Conclusion: Our data indicate that the changed glucose metabolism in cerebral regions in F-18-FDG-PET imaging could be an important predictor for early AD. |
| 电子版国际标准刊号 | 1938-2731 |
| 语种 | 英语 |
| WOS记录号 | WOS:000376305200005 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/287072]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Huang, Y,Chen, JQ,Cui, SY,et al. Cerebral Glucose Metabolism Assessment in Rat Models of Alzheimer's Disease: An F-18-FDG-PET Study[J]. AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS,2016,31(4):333-340. |
| APA | Huang, Y.,Chen, JQ.,Cui, SY.,Ren, J.,Lu, YJ.,...&Tang, CZ.(2016).Cerebral Glucose Metabolism Assessment in Rat Models of Alzheimer's Disease: An F-18-FDG-PET Study.AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS,31(4),333-340. |
| MLA | Huang, Y,et al."Cerebral Glucose Metabolism Assessment in Rat Models of Alzheimer's Disease: An F-18-FDG-PET Study".AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS 31.4(2016):333-340. |
入库方式： OAI收割
来源：高能物理研究所
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