Nonlinear Mechanical Modeling Of Cell Adhesion
文献类型：期刊论文
| 作者 | Kong D(孔冬) ; Ji BH(季葆华); Dai LH(戴兰宏)
|
| 刊名 | Journal of Theoretical Biology
 |
| 出版日期 | 2008 |
| 页码 | 75-84 |
| 通讯作者邮箱 | bhji@tsinghua.edu.cn ; lhdai@lnm.imech.ac.cn |
| 关键词 | Cell Adhesion Focal Adhesions Nonlinear Receptor-Ligand Bonds Force-Extension Relationship Bond Density Membrane-Membrane Adhesion Molecular Cross-Bridges Detailed Mechanics Focal Contacts Detachment Kinetics Activation Attachment Separation Nanoscale |
| ISSN号 | 0022-5193 |
| 通讯作者 | Ji, BH (reprint author), Tsing Hua Univ, Dept Engn Mech, Beijing 100084, Peoples R China. |
| 中文摘要 | Cell adhesion, which is mediated by the receptor-ligand bonds, plays an essential role in various biological processes. Previous studies often described the force-extension relationship of receptor-ligand bond with linear assumption. However, the force-extension relationship of the bond is intrinsically nonlinear, which should have significant influence on the mechanical behavior of cell adhesion. In this work, a nonlinear mechanical model for cell adhesion is developed, and the adhesive strength was studied at various bond distributions. We find that the nonlinear mechanical behavior of the receptor-ligand bonds is crucial to the adhesive strength and stability. This nonlinear behavior allows more bonds to achieve large bond force simultaneously, and therefore the adhesive strength becomes less sensitive to the change of bond density at the outmost periphery of the adhesive area. In this way, the strength and stability of cell adhesion are soundly enhanced. The nonlinear model describes the cell detachment behavior better than the linear model. (C) 2007 Elsevier Ltd. All rights reserved. |
| 类目[WOS] | Biology ; Mathematical & Computational Biology |
| 研究领域[WOS] | Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology |
| 关键词[WOS] | MEMBRANE-MEMBRANE ADHESION ; MOLECULAR CROSS-BRIDGES ; DETAILED MECHANICS ; FOCAL CONTACTS ; DETACHMENT ; KINETICS ; ACTIVATION ; ATTACHMENT ; SEPARATION ; NANOSCALE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000252472200007 |
| 公开日期 | 2009-08-03 ; 2009-09-14 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/26154]  |
| 专题 | 力学研究所_力学所知识产出(1956-2008) |
| 推荐引用方式 GB/T 7714 | Kong D,Ji BH,Dai LH. Nonlinear Mechanical Modeling Of Cell Adhesion[J]. Journal of Theoretical Biology,2008:75-84. |
| APA | 孔冬,季葆华,&戴兰宏.(2008).Nonlinear Mechanical Modeling Of Cell Adhesion.Journal of Theoretical Biology,75-84. |
| MLA | 孔冬,et al."Nonlinear Mechanical Modeling Of Cell Adhesion".Journal of Theoretical Biology (2008):75-84. |
入库方式： OAI收割
来源：力学研究所
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