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Formation of porous Cu hydroxy double salt nanoflowers derived from metal-organic frameworks with efficient peroxidase-like activity for label-free detection of glucose

文献类型：期刊论文

作者Li, AL; Mu, XJ; Li, TR; Wen, H1; Li, WC; Li, YE; Wang, BD
刊名NANOSCALE
出版日期2018-07-07
卷号10期号:25页码:11948-11954
ISSN号2040-3364
DOI10.1039/c8nr02832j
英文摘要Currently, nanomaterials with peroxidase activity have become an important colorimetric tool for biomolecular detection. However, compared with natural enzymes, the efficiency of most nanozymes is still lower. Here, with a leaf-like metal-organic-framework-5 as both a precursor and a template and copper acetate as a second precursor, hierarchical Cu hydroxy double salt (HDS) nanoflowers have been prepared and used as a label-free glucose colorimetric detection platform. We have demonstrated a scalable and facile synthesis of hierarchical Cu HDS nanoflowers, and density functional theory (DFT) calculations confirmed that there exists a hydrogen bond between the terephthalate anions and the layer OH group. The composition of Cu hydroxyl double salt is [Cu-4(OH)(6)][BDC]2H(2)O. Importantly, for the first time, the as-prepared Cu HDSs were demonstrated as peroxidase mimics to catalyze the oxidation of the enzyme substrate, 3,5,5-tetramethylbenzidine (TMB) in the presence of H2O2, which accompanies a color change from colorless to blue and followed classic Michaelis-Menten models. Based on these findings, a colorimetric method based on Cu HDSs that is highly sensitive and selective for the detection of glucose was developed, with a low detection limit of 0.5 M. The clinical applicability of the sensor is also proven to be suitable for sensing glucose in blood, suggesting that Cu HDSs could be used in the construction of portable sensors for point-of-care diagnosis and on-site tests.
学科主题Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
语种英语
WOS记录号WOS:000437761500026
源URL[http://ir.imr.ac.cn/handle/321006/80103]  
专题金属研究所_中国科学院金属研究所
作者单位1.Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China
2.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
3.Lanzhou Univ, Sch Informat Sci & Engn, Lanzhou 730000, Gansu, Peoples R China
4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式
GB/T 7714		 Li, AL,Mu, XJ,Li, TR,et al. Formation of porous Cu hydroxy double salt nanoflowers derived from metal-organic frameworks with efficient peroxidase-like activity for label-free detection of glucose[J]. NANOSCALE,2018,10(25):11948-11954.
APA Li, AL.,Mu, XJ.,Li, TR.,Wen, H.,Li, WC.,...&Wang, BD.(2018).Formation of porous Cu hydroxy double salt nanoflowers derived from metal-organic frameworks with efficient peroxidase-like activity for label-free detection of glucose.NANOSCALE,10(25),11948-11954.
MLA Li, AL,et al."Formation of porous Cu hydroxy double salt nanoflowers derived from metal-organic frameworks with efficient peroxidase-like activity for label-free detection of glucose".NANOSCALE 10.25(2018):11948-11954.

入库方式： OAI收割

来源：金属研究所

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