In vitro and in vivo studies of anti-bacterial copper-bearing titanium alloy for dental application
文献类型：期刊论文
| 作者 | Liu, R1; Tang, YL; Zeng, LL; Zhao, Y3; Ma, Z; Sun, ZQ; Xiang, LB; Ren, L; Yang, K |
| 刊名 | DENTAL MATERIALS
 |
| 出版日期 | 2018-08-01 |
| 卷号 | 34期号:8页码:1112-1126 |
| 关键词 | Dental implants Titanium Copper Anti-bacterial Biofilm Peri-implantitis |
| ISSN号 | 0109-5641 |
| DOI | 10.1016/j.dental.2018.04.007 |
| 英文摘要 | Objective. A novel copper-bearing titanium alloy (Ti-Cu) was fabricated for dental application that is expected to efficiently restrain the growth of bacteria and discourage biofilm formation. The aim of this study was to investigate both the antibacterial activity and biofilm inhibition of Ti-Cu alloy in vitro, and the antibacterial effect of Ti-Cu implant in early stage of peri-implantitis in vivo. Methods. Staphylococcus aureus and Escherichia coli were selected to evaluate the antibacterial activity of Ti-Cu alloy and Ti served as control. The antibacterial rate, attached bacteria and developed biofilms were studied from quantitative antibacterial test, biofilm observation and bacterial morphological examination. Electrochemical tests were used to investigate the corrosion property of Ti-Cu alloy. Furthermore, both Ti and Ti-Cu dental implants were manufactured and then implanted in the mandibular premolar sites of beagle dogs for 3 months with ligature-infected treatment. Implant-tissue samples were prepared for radiographic analysis, Micro-CT evaluation and histological examination. Results. Ti-Cu alloy was found to efficiently kill the attached bacteria by ways of damaging cell membranes and cell walls and strongly inhibit the biofilm formation. However, Ti-Cu alloy had excellent corrosion resistance similar with Ti. Further, Ti-Cu dental implants showed superior capacities of inhibiting the bone resorption caused by bacterial infection and enhancing bone formation. Significance. Ti-Cu alloy strongly inhibited biofilm formation in vitro and prevented bacterial infection associated with dental implant in vivo, making it great potential for application in dental implants with excellent antibacterial viability and positive effect against bone resorption induced by peri-implantitis. (C) 2018 The Academy of Dental Materials. Published by Elsevier Inc. All rights reserved. |
| 学科主题 | Dentistry, Oral Surgery & Medicine ; Materials Science, bioMaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000437677600006 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/80062]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China 2.Northeastern Univ, 3-11 Wenhua Rd, Shenyang 110819, Liaoning, Peoples R China 3.Gen Hosp Shenyang Mil Area, Dept Stomatol, Shenyang 110016, Liaoning, Peoples R China 4.Chinese Acad Sci, Ctr Human Tissues & Organs Degenerat, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China 5.Gen Hosp Shenyang Mil Area, Dept Orthoped, Shenyang 110016, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, R,Tang, YL,Zeng, LL,et al. In vitro and in vivo studies of anti-bacterial copper-bearing titanium alloy for dental application[J]. DENTAL MATERIALS,2018,34(8):1112-1126. |
| APA | Liu, R.,Tang, YL.,Zeng, LL.,Zhao, Y.,Ma, Z.,...&Yang, K.(2018).In vitro and in vivo studies of anti-bacterial copper-bearing titanium alloy for dental application.DENTAL MATERIALS,34(8),1112-1126. |
| MLA | Liu, R,et al."In vitro and in vivo studies of anti-bacterial copper-bearing titanium alloy for dental application".DENTAL MATERIALS 34.8(2018):1112-1126. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。