In vitro study of stimulation effect on endothelialization by a copper bearing cobalt alloy
文献类型：期刊论文
| 作者 | Jin, SJ; Qi, X; Wang, TM; Ren, L; Yang, K; Zhong, HS; Ren, L (reprint author), Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China. |
| 刊名 | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
 |
| 出版日期 | 2018-02-01 |
| 卷号 | 106期号:2页码:561-569 |
| 关键词 | Stent Restenosis Angiogenesis Cells Expression Release |
| ISSN号 | 1549-3296 |
| 英文摘要 | Endothelialization is an important process after stenting in coronary artery. Recovery of the injured site timely can reduce the neointima formation and platelet absorbance, leading to a lower risk of in-stent restenosis. Copper is known to be critical in vascular construction. Thus a combination of copper with stent materials is a meaningful attempt. A copper bearing L605-Cu cobalt alloy was prepared and its effect on human umbilical vein endothelial cells (HUVECs) was evaluated in vitro in this study. It was found that HUVECs attached and stretched better on the surface of L605-Cu compared with L605, and the apoptosis of cells was decreased simultaneously. The migration and tube formation of HUVECs were also enhanced by the extract of L605-Cu. Furthermore, L605-Cu increased the mRNA expression of VEGF in HUVECs significantly. However it had no effect on the secretion of NO or mRNA expression of eNOS. The result of blood clotting test indicated that L605-Cu had better blood compatibility. These results above have demonstrated that the L605-Cu alloy is promising to be a new stent material with function of accelerating endothelialization. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 561-569, 2018.; Endothelialization is an important process after stenting in coronary artery. Recovery of the injured site timely can reduce the neointima formation and platelet absorbance, leading to a lower risk of in-stent restenosis. Copper is known to be critical in vascular construction. Thus a combination of copper with stent materials is a meaningful attempt. A copper bearing L605-Cu cobalt alloy was prepared and its effect on human umbilical vein endothelial cells (HUVECs) was evaluated in vitro in this study. It was found that HUVECs attached and stretched better on the surface of L605-Cu compared with L605, and the apoptosis of cells was decreased simultaneously. The migration and tube formation of HUVECs were also enhanced by the extract of L605-Cu. Furthermore, L605-Cu increased the mRNA expression of VEGF in HUVECs significantly. However it had no effect on the secretion of NO or mRNA expression of eNOS. The result of blood clotting test indicated that L605-Cu had better blood compatibility. These results above have demonstrated that the L605-Cu alloy is promising to be a new stent material with function of accelerating endothelialization. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 561-569, 2018. |
| 学科主题 | Engineering, Biomedical ; Materials Science, bioMaterials |
| 语种 | 英语 |
| 资助机构 | National Natural Science Foundation [81301329, 81571778, 81201168]; Joint foundation of Liaoning Province Natural Science Foundation and Shenyang National Laboratory for materials science [2015021004]; Youth Innovation Promotion Association, CAS [2014168]; Natural Science Foundation of Guangdong province [2015A030312004]; Natural Science Foundation of Liaoning Province [201602850] |
| 公开日期 | 2018-06-05 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/79556]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Ren, L (reprint author), Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Jin, SJ,Qi, X,Wang, TM,et al. In vitro study of stimulation effect on endothelialization by a copper bearing cobalt alloy[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2018,106(2):561-569. |
| APA | Jin, SJ.,Qi, X.,Wang, TM.,Ren, L.,Yang, K.,...&Ren, L .(2018).In vitro study of stimulation effect on endothelialization by a copper bearing cobalt alloy.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,106(2),561-569. |
| MLA | Jin, SJ,et al."In vitro study of stimulation effect on endothelialization by a copper bearing cobalt alloy".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 106.2(2018):561-569. |
入库方式： OAI收割
来源：金属研究所
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