Surface nanotopography-induced favorable modulation of bioactivity and osteoconductive potential of anodized 3D printed Ti-6Al-4V alloy mesh structure
文献类型：期刊论文
| 作者 | Nune, KC; Misra, RDK; Gai, X; Li, SJ; Hao, YL; Misra, RDK (reprint author), Univ Texas El Paso, 500 W Univ Ave Engn Bldg,Met Engn M201, El Paso, TX 79968 USA. |
| 刊名 | JOURNAL OF BIOMATERIALS APPLICATIONS
 |
| 出版日期 | 2018-03-01 |
| 卷号 | 32期号:8页码:1032-1048 |
| ISSN号 | 0885-3282 |
| 关键词 | Titanium-oxide Nanotubes Treated Porous Titanium Micro-arc Oxidation In-vitro Antiinflammatory Properties Biomedical Applications Tio2 Nanotubes Hydrothermal Treatment Osteoblast Functions Functional-response |
| 英文摘要 | The objective of the study described here is to fundamentally elucidate the biological response of 3D printed Ti-6Al-4V alloy mesh structures that were surface modified to introduce titania nanotubes with an average pore size of approximate to 80nm via an electrochemical anodization process from the perspective of enhancing bioactivity. The bioactivity of the mesh structures were analyzed through immersion test in simulated body fluid, which confirmed the nucleation and growth of fine globular nanoscale apatite on the nanoporous titania-modified (anodized) mesh structure surface, and agglomerated apatite with fine flakes of apatite crystals on as-fabricated mesh structure surface, that were rich in calcium and phosphorous. The cellular activity of bioactive anodized mesh structure was explored in terms of cell-material interactions involving adhesion, proliferation, synthesis of extracellular and intracellular proteins, differentiation, and mineralization. Cells adhered with a sheet-like morphology on as-fabricated mesh structure, whereas, on anodized mesh structure, numerous filopodia-like cellular extensions interacting with nanotube pores were observed. The formation of a bioactive nanoscale apatite, cell-nanotube interactions as imaged via electron microscopy, higher expression of proteins (actin, vinculin, fibronectin, and alkaline phosphatase (ALP)), and calcium content points toward the determining role of anodized mesh structure in modulating osteoblasts functions. The unique combination of nanoporous bioactive titania and interconnected porous architecture of anodized titanium alloy mesh structure provided a multimodal roughness surface ranging from nano to micro to macroscale, which helps in attaining strong primary and secondary fixation of the implant device along with the pathway for supply of nutrients and oxygen to cells and tissue.; The objective of the study described here is to fundamentally elucidate the biological response of 3D printed Ti-6Al-4V alloy mesh structures that were surface modified to introduce titania nanotubes with an average pore size of approximate to 80nm via an electrochemical anodization process from the perspective of enhancing bioactivity. The bioactivity of the mesh structures were analyzed through immersion test in simulated body fluid, which confirmed the nucleation and growth of fine globular nanoscale apatite on the nanoporous titania-modified (anodized) mesh structure surface, and agglomerated apatite with fine flakes of apatite crystals on as-fabricated mesh structure surface, that were rich in calcium and phosphorous. The cellular activity of bioactive anodized mesh structure was explored in terms of cell-material interactions involving adhesion, proliferation, synthesis of extracellular and intracellular proteins, differentiation, and mineralization. Cells adhered with a sheet-like morphology on as-fabricated mesh structure, whereas, on anodized mesh structure, numerous filopodia-like cellular extensions interacting with nanotube pores were observed. The formation of a bioactive nanoscale apatite, cell-nanotube interactions as imaged via electron microscopy, higher expression of proteins (actin, vinculin, fibronectin, and alkaline phosphatase (ALP)), and calcium content points toward the determining role of anodized mesh structure in modulating osteoblasts functions. The unique combination of nanoporous bioactive titania and interconnected porous architecture of anodized titanium alloy mesh structure provided a multimodal roughness surface ranging from nano to micro to macroscale, which helps in attaining strong primary and secondary fixation of the implant device along with the pathway for supply of nutrients and oxygen to cells and tissue. |
| 学科主题 | Engineering, Biomedical ; Materials Science, bioMaterials |
| 语种 | 英语 |
| 公开日期 | 2018-06-05 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/79443]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Misra, RDK (reprint author), Univ Texas El Paso, 500 W Univ Ave Engn Bldg,Met Engn M201, El Paso, TX 79968 USA. |
| 推荐引用方式 GB/T 7714 | Nune, KC,Misra, RDK,Gai, X,et al. Surface nanotopography-induced favorable modulation of bioactivity and osteoconductive potential of anodized 3D printed Ti-6Al-4V alloy mesh structure[J]. JOURNAL OF BIOMATERIALS APPLICATIONS,2018,32(8):1032-1048. |
| APA | Nune, KC,Misra, RDK,Gai, X,Li, SJ,Hao, YL,&Misra, RDK .(2018).Surface nanotopography-induced favorable modulation of bioactivity and osteoconductive potential of anodized 3D printed Ti-6Al-4V alloy mesh structure.JOURNAL OF BIOMATERIALS APPLICATIONS,32(8),1032-1048. |
| MLA | Nune, KC,et al."Surface nanotopography-induced favorable modulation of bioactivity and osteoconductive potential of anodized 3D printed Ti-6Al-4V alloy mesh structure".JOURNAL OF BIOMATERIALS APPLICATIONS 32.8(2018):1032-1048. |
入库方式： OAI收割
来源：金属研究所
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