Effects of scandium addition on biocompatibility of biodegradable Mg-1.5Zn-0.6Zr alloy
文献类型：期刊论文
| 作者 | Li, T; He, Y; Zhou, JX; Tang, SQ; Yang, YS; Wang, XT; Li, T (reprint author), Shandong Acad Sci, Adv Mat Inst, Shandong Key Lab High Strength Lightweight Metall, Jinan 250014, Shandong, Peoples R China.; Wang, XT (reprint author), Univ Sci & Technol Beijing, Collaborat Innovat Ctr Steel Technol, Beijing 100083, Peoples R China. |
| 刊名 | MATERIALS LETTERS
 |
| 出版日期 | 2018-03-15 |
| 卷号 | 215页码:200-202 |
| 关键词 | Rare-earth-elements In-vitro Degradation Magnesium Alloys Cell-lines Corrosion Behavior Microstructure Implants Metals |
| ISSN号 | 0167-577X |
| 英文摘要 | Heretofore, the effects of scandium on the biocompatibility of biodegradable magnesium alloys are extremely limited recognized. In the present study, four Mg-1.5Zn-0.6Zr-xSc (x = 0, 0.2, 0.5, 1.0 wt%) alloys were fabricated and their hydrophilicity, cytotoxicity, and hemocompatibility were investigated. The contact angle measurements revealed that addition of Sc improved the hydrophilicity of the alloys. For biodegradable alloys, perfect hydrophilicity could promote the tissue attaching on implant surface, establishing a benign biological reaction and improving the therapeutic effectiveness. The viabilities of L-929 cells and SP2/0 cells for all the alloys were about 100% and 90% compared to negative control, respectively. No obvious differences existed in cell viabilities between different Sc contents. With increasing addition of Sc, the hemolysis percentages and the degree of platelet activation increased. It deteriorated the hemocompatibility of the alloys. Proteomics, genomics, and in vivo investigations are needed in the future to get more deep understandings of the biocompatibility of Sc. (C) 2017 Elsevier B.V. All rights reserved.; Heretofore, the effects of scandium on the biocompatibility of biodegradable magnesium alloys are extremely limited recognized. In the present study, four Mg-1.5Zn-0.6Zr-xSc (x = 0, 0.2, 0.5, 1.0 wt%) alloys were fabricated and their hydrophilicity, cytotoxicity, and hemocompatibility were investigated. The contact angle measurements revealed that addition of Sc improved the hydrophilicity of the alloys. For biodegradable alloys, perfect hydrophilicity could promote the tissue attaching on implant surface, establishing a benign biological reaction and improving the therapeutic effectiveness. The viabilities of L-929 cells and SP2/0 cells for all the alloys were about 100% and 90% compared to negative control, respectively. No obvious differences existed in cell viabilities between different Sc contents. With increasing addition of Sc, the hemolysis percentages and the degree of platelet activation increased. It deteriorated the hemocompatibility of the alloys. Proteomics, genomics, and in vivo investigations are needed in the future to get more deep understandings of the biocompatibility of Sc. (C) 2017 Elsevier B.V. All rights reserved. |
| 学科主题 | Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| 资助机构 | National Natural Science Foundation of China [51174025]; National Key Research and Development Program of China [2016YFB0301105]; Shandong Academy of Sciences of China [2018QN0034]; Shandong Provincial Natural Science Foundation of China [ZR2017LEM002] |
| 公开日期 | 2018-06-05 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/79428]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 通讯作者 | Li, T (reprint author), Shandong Acad Sci, Adv Mat Inst, Shandong Key Lab High Strength Lightweight Metall, Jinan 250014, Shandong, Peoples R China.; Wang, XT (reprint author), Univ Sci & Technol Beijing, Collaborat Innovat Ctr Steel Technol, Beijing 100083, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Li, T,He, Y,Zhou, JX,et al. Effects of scandium addition on biocompatibility of biodegradable Mg-1.5Zn-0.6Zr alloy[J]. MATERIALS LETTERS,2018,215:200-202. |
| APA | Li, T.,He, Y.,Zhou, JX.,Tang, SQ.,Yang, YS.,...&Wang, XT .(2018).Effects of scandium addition on biocompatibility of biodegradable Mg-1.5Zn-0.6Zr alloy.MATERIALS LETTERS,215,200-202. |
| MLA | Li, T,et al."Effects of scandium addition on biocompatibility of biodegradable Mg-1.5Zn-0.6Zr alloy".MATERIALS LETTERS 215(2018):200-202. |
入库方式： OAI收割
来源：金属研究所
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