Searchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms
文献类型:期刊论文
作者 | Wang, Yong-ming1,2,3,4; Cai, Xin-lu1,2,3,4; Zhang, Rui-ting1,4; Wang, Yi1,4; Madsen, Kristoffer Hougaard3,5,6; Sorensen, Thomas Alrik3,7; Moller, Arne3,8,9; Cheung, Eric F. C.10; Chan, Raymond C. K.1,2,3,4 |
刊名 | COGNITIVE NEUROPSYCHIATRY |
出版日期 | 2019-08-28 |
页码 | 13 |
ISSN号 | 1354-6805 |
关键词 | Obsessive-compulsive symptoms searchlight Amplitude of Low Frequency Fluctuation functional connectivity |
DOI | 10.1080/13546805.2019.1658575 |
产权排序 | 1 |
文献子类 | article |
英文摘要 | Introduction Investigating obsessive-compulsive symptoms in subclinical populations provides a useful framework for understanding the early development of obsessive-compulsive spectrum disorders. The present study aimed to apply searchlight classification analysis on resting-state functional magnetic resonance imaging data to identify potential brain markers in subclinical individuals with obsessive-compulsive symptoms. Methods In this observational study, 40 college students with high obsessive-compulsive symptom scores and 40 with low obsessive-compulsive symptom scores were recruited from universities in China. We conducted searchlight classification and comparison analysis between the two groups based on Amplitude of Low Frequency Fluctuation (ALFF), fraction ALFF (fALFF) and resting-state functional connectivity using searchlight classification. Results We found that the highest accuracy rate in differentiating between the two groups was 85.00%. Significant discriminating features included the ALFF of the left medial superior frontal gyrus and the functional connectivity between the right thalamus and the bilateral medial superior frontal gyrus, and the right putamen, as well as the functional connectivity between the left caudate and the right insula. Conclusions These findings highlight the specific and distinguishing brain functional abnormalities associated with obsessive-compulsive symptoms. |
WOS关键词 | GENOME-WIDE ASSOCIATION ; PERSONALITY-TRAITS ; DISORDER EVIDENCE ; TENDENCIES ; FMRI ; INVENTORY ; NEUROPSYCHOLOGY ; VALIDATION ; ACTIVATION ; CIRCUITS |
资助项目 | National Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission Grant[Z161100000216138] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; Chinese Academy of Science[XDB02030002] ; CAS Key Laboratory of Mental Health, Institute of Psychology |
WOS研究方向 | Psychiatry |
语种 | 英语 |
出版者 | ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD |
WOS记录号 | WOS:000483718100001 |
资助机构 | National Key Research and Development Programme ; Beijing Municipal Science & Technology Commission Grant ; Beijing Training Project for the Leading Talents in S T ; Chinese Academy of Science ; CAS Key Laboratory of Mental Health, Institute of Psychology |
源URL | [http://ir.psych.ac.cn/handle/311026/29800] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Chan, Raymond C. K. |
作者单位 | 1.Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China 3.Sino Danish Ctr Educ & Res, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Copenhagen Univ Hosp Hvidovre, Ctr Funct & Diagnost Imaging & Res, Danish Res Ctr Magnet Resonance, Hvidovre, Denmark 6.Tech Univ Denmark, Dept Appl Math & Comp Sci, Lyngby, Denmark 7.Aalborg Univ, Dept Commun & Psychol, Ctr Cognit Neurosci, Aalborg, Denmark 8.Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark 9.Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark 10.Castle Peak Hosp, Hong Kong, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Yong-ming,Cai, Xin-lu,Zhang, Rui-ting,et al. Searchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms[J]. COGNITIVE NEUROPSYCHIATRY,2019:13. |
APA | Wang, Yong-ming.,Cai, Xin-lu.,Zhang, Rui-ting.,Wang, Yi.,Madsen, Kristoffer Hougaard.,...&Chan, Raymond C. K..(2019).Searchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms.COGNITIVE NEUROPSYCHIATRY,13. |
MLA | Wang, Yong-ming,et al."Searchlight classification based on Amplitude of Low Frequency Fluctuation and functional connectivity in individuals with obsessive-compulsive symptoms".COGNITIVE NEUROPSYCHIATRY (2019):13. |
入库方式: OAI收割
来源:心理研究所
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