Altered transposition asymmetry in serial ordering in early Parkinson's disease
文献类型:期刊论文
作者 | Ma, Shaoyang1,2; Zhang, Yingshuang3; Liu, Na3; Xiao, Weizhong3; Li, Shuaiqi4; Zhang, Guanyu1,2; Zhou, Xiaolin4,5; Muente, Thomas F.6; Ye, Zheng7 |
刊名 | PARKINSONISM & RELATED DISORDERS |
出版日期 | 2019-05-01 |
卷号 | 62页码:62-67 |
ISSN号 | 1353-8020 |
关键词 | Parkinson's disease D2/3 receptor Serial ordering Anticipation Fill-in |
DOI | 10.1016/j.parkreldis.2019.01.028 |
产权排序 | 1 |
文献子类 | article |
英文摘要 | Introduction: The ability to arrange thoughts and actions in an appropriate serial order is impaired in Parkinson's disease (PD). However, it is unclear how serial order is represented and manipulated and how the representation or manipulation is altered in the early stages of PD. We aimed to analyze the pattern of performance errors in serial ordering versus serial recall in nondemented PD patients with mild clinical symptoms and healthy adults to identify the underlying principles of serial ordering. Methods: PD patients (N = 57) and healthy controls (N = 40) completed the adaptive digit ordering and digit span forward tests. We focused on items recalled in incorrect positions (transposition) and analyzed the tendency to recall transposed items too early (anticipation) versus too late (postponement). We also analyzed the tendency to recall the item displaced by the error (fill-in) versus the item following the error in the target output order (infill) after anticipation errors. Results: PD patients not only made more transposition errors but also showed distinct error patterns. The patients made more anticipations but not postponements, and more fill-ins but not in fills than healthy controls in the ordering test (transposition asymmetry). Individual patients' percentage of anticipations was negatively correlated with their daily exposure to D2/3 receptor agonists. Patients' error pattern in the forward test was normal. Conclusion: The increase in anticipations in PD suggests an increase in the forward-specific variability in the representation of serial order. Their increase in fill-ins suggests a deficit in the chaining mechanism involved in the manipulation of serial order. |
WOS关键词 | WORKING-MEMORY ; COGNITIVE IMPAIRMENT ; MODEL ; COMPREHENSION ; DEFICITS ; TASK |
资助项目 | National Natural Science Foundation of China[31771216] ; Thousand Young Talents Program ; Alexander von Humboldt Foundation ; German Research Foundation[SFB TR134 C1] |
WOS研究方向 | Neurosciences & Neurology |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000476961700010 |
资助机构 | National Natural Science Foundation of China ; Thousand Young Talents Program ; Alexander von Humboldt Foundation ; German Research Foundation |
源URL | [http://ir.psych.ac.cn/handle/311026/29603] |
专题 | 心理研究所_健康与遗传心理学研究室 |
通讯作者 | Muente, Thomas F.; Ye, Zheng |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Peking Univ, Hosp 3, Dept Neurol, Beijing, Peoples R China 4.Peking Univ, Sch Psychol & Cognit Sci, Ctr Brain & Cognit Sci, Beijing, Peoples R China 5.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing, Peoples R China 6.Univ Lubeck, Dept Neurol, Ratzeburger Allee 160, D-23538 Lubeck, Germany 7.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Neurosci,Key Lab Primate Neurobiol, Shanghai, Peoples R China |
推荐引用方式 GB/T 7714 | Ma, Shaoyang,Zhang, Yingshuang,Liu, Na,et al. Altered transposition asymmetry in serial ordering in early Parkinson's disease[J]. PARKINSONISM & RELATED DISORDERS,2019,62:62-67. |
APA | Ma, Shaoyang.,Zhang, Yingshuang.,Liu, Na.,Xiao, Weizhong.,Li, Shuaiqi.,...&Ye, Zheng.(2019).Altered transposition asymmetry in serial ordering in early Parkinson's disease.PARKINSONISM & RELATED DISORDERS,62,62-67. |
MLA | Ma, Shaoyang,et al."Altered transposition asymmetry in serial ordering in early Parkinson's disease".PARKINSONISM & RELATED DISORDERS 62(2019):62-67. |
入库方式: OAI收割
来源:心理研究所
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