On the Binding of Cationic, Water-Soluble Conjugated Polymers to DNA: Electrostatic and Hydrophobic Interactions
文献类型：期刊论文
| 作者 | Xia, Fan1,2,3; Zuo, Xiaolei3; Yang, Renqiang4 ; Xiao, Yi3; Kang, Di3; Vallee-Belisle, Alexis3; Gong, Xiong1,2; Heeger, Alan J.1,2; Plaxco, Kevin W.3
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| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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| 出版日期 | 2010-02-03 |
| 卷号 | 132期号:4页码:1252-+ |
| ISSN号 | 0002-7863 |
| 中文摘要 | Water-soluble, cationic conjugated polymer binds single-stranded DNA with higher affinity than it binds double-stranded or otherwise "folded" DNA. This stronger binding results from the greater hydrophobicity of single-stranded DNA. Upon reducing the strength of the hydrophobic interactions, the electrostatic attraction becomes the important interaction that regulates the binding between the water-soluble conjugated polymer and DNA. The different affinities between the cationic conjugated polymer and various Forms of DNA (molecular beacons and its open state; single-stranded DNA and double-stranded DNA and single-stranded DNA and complex DNA folds) can be used to design a variety of biosensors. |
| 英文摘要 | Water-soluble, cationic conjugated polymer binds single-stranded DNA with higher affinity than it binds double-stranded or otherwise "folded" DNA. This stronger binding results from the greater hydrophobicity of single-stranded DNA. Upon reducing the strength of the hydrophobic interactions, the electrostatic attraction becomes the important interaction that regulates the binding between the water-soluble conjugated polymer and DNA. The different affinities between the cationic conjugated polymer and various Forms of DNA (molecular beacons and its open state; single-stranded DNA and double-stranded DNA and single-stranded DNA and complex DNA folds) can be used to design a variety of biosensors. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 学科主题 | 先进功能有机材料 |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | ENERGY-TRANSFER ; THERMODYNAMIC BASIS ; GOLD NANOPARTICLES ; MOLECULAR BEACONS ; PROBES ; OLIGONUCLEOTIDES ; POLYELECTROLYTE ; POLYTHIOPHENE ; HYBRIDIZATION ; SPECIFICITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000275084800034 |
| 公开日期 | 2011-09-09 |
| 源URL | [http://ir.qibebt.ac.cn//handle/337004/498]  |
| 专题 | 青岛生物能源与过程研究所_先进有机功能材料团队 |
| 作者单位 | 1.Univ Calif Santa Barbara, Ctr Polymers & Organ Solids, Santa Barbara, CA 93106 USA 2.Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA 3.Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA 4.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia, Fan,Zuo, Xiaolei,Yang, Renqiang,et al. On the Binding of Cationic, Water-Soluble Conjugated Polymers to DNA: Electrostatic and Hydrophobic Interactions[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2010,132(4):1252-+. |
| APA | Xia, Fan.,Zuo, Xiaolei.,Yang, Renqiang.,Xiao, Yi.,Kang, Di.,...&Plaxco, Kevin W..(2010).On the Binding of Cationic, Water-Soluble Conjugated Polymers to DNA: Electrostatic and Hydrophobic Interactions.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,132(4),1252-+. |
| MLA | Xia, Fan,et al."On the Binding of Cationic, Water-Soluble Conjugated Polymers to DNA: Electrostatic and Hydrophobic Interactions".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132.4(2010):1252-+. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
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