Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols
文献类型：期刊论文
| 作者 | Yu, Chao; Cao, Yujin; Zou, Huibin; Xian, Mo
|
| 刊名 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
 |
| 出版日期 | 2011-02-01 |
| 卷号 | 89期号:3页码:573-583 |
| 关键词 | Escherichia coli Metabolic pathway Organic acid Alcohol Platform chemicals |
| ISSN号 | 0175-7598 |
| 中文摘要 | Confronted with the gradual and inescapable exhaustion of the earth's fossil energy resources, the bio-based process to produce platform chemicals from renewable carbohydrates is attracting growing interest. Escherichia coli has been chosen as a workhouse for the production of many valuable chemicals due to its clear genetic background, convenient to be genetically modified and good growth properties with low nutrient requirements. Rational strain development of E. coli achieved by metabolic engineering strategies has provided new processes for efficiently biotechnological production of various high-value chemical building blocks. Compared to previous reviews, this review focuses on recent advances in metabolic engineering of the industrial model bacteria E. coli that lead to efficient recombinant biocatalysts for the production of high-value organic acids like succinic acid, lactic acid, 3-hydroxypropanoic acid and glucaric acid as well as alcohols like 1,3-propanediol, xylitol, mannitol, and glycerol with the discussion of the future research in this area. Besides, this review also discusses several platform chemicals, including fumaric acid, aspartic acid, glutamic acid, sorbitol, itaconic acid, and 2,5-furan dicarboxylic acid, which have not been produced by E. coli until now. |
| 英文摘要 | Confronted with the gradual and inescapable exhaustion of the earth's fossil energy resources, the bio-based process to produce platform chemicals from renewable carbohydrates is attracting growing interest. Escherichia coli has been chosen as a workhouse for the production of many valuable chemicals due to its clear genetic background, convenient to be genetically modified and good growth properties with low nutrient requirements. Rational strain development of E. coli achieved by metabolic engineering strategies has provided new processes for efficiently biotechnological production of various high-value chemical building blocks. Compared to previous reviews, this review focuses on recent advances in metabolic engineering of the industrial model bacteria E. coli that lead to efficient recombinant biocatalysts for the production of high-value organic acids like succinic acid, lactic acid, 3-hydroxypropanoic acid and glucaric acid as well as alcohols like 1,3-propanediol, xylitol, mannitol, and glycerol with the discussion of the future research in this area. Besides, this review also discusses several platform chemicals, including fumaric acid, aspartic acid, glutamic acid, sorbitol, itaconic acid, and 2,5-furan dicarboxylic acid, which have not been produced by E. coli until now. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biotechnology & Applied Microbiology |
| 研究领域[WOS] | Biotechnology & Applied Microbiology |
| 关键词[WOS] | WHOLE-CELL BIOTRANSFORMATION ; MINERAL SALTS MEDIUM ; D-MANNITOL FORMATION ; L-LACTIC ACID ; SUCCINATE PRODUCTION ; 3-HYDROXYPROPIONIC ACID ; XYLITOL PRODUCTION ; PHOSPHOENOLPYRUVATE CARBOXYLASE ; CORYNEBACTERIUM-GLUTAMICUM ; GLUTAMATE PRODUCTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000286429400010 |
| 公开日期 | 2011-09-13 |
| 源URL | [http://ir.qibebt.ac.cn//handle/337004/680]  |
| 专题 | 青岛生物能源与过程研究所_材料生物技术研究中心 |
| 作者单位 | Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biofuels, Qingdao 266101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Chao,Cao, Yujin,Zou, Huibin,et al. Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2011,89(3):573-583. |
| APA | Yu, Chao,Cao, Yujin,Zou, Huibin,&Xian, Mo.(2011).Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,89(3),573-583. |
| MLA | Yu, Chao,et al."Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 89.3(2011):573-583. |
入库方式： OAI收割
来源：青岛生物能源与过程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。