Telomeric noncoding RNA promotes mouse embryonic stem cell self-renewal through inhibition of TCF3 activity
文献类型：期刊论文
| 作者 | Xu, Xiaojuan1,2; Guo, Mengmeng3; Zhang, Na1 ; Ye, Shoudong3
|
| 刊名 | AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
 |
| 出版日期 | 2018-06-01 |
| 卷号 | 314期号:6页码:C712-C720 |
| 关键词 | CHIR mouse embryonic stem cells self-renewal TCF3 TERRA |
| ISSN号 | 0363-6143 |
| DOI | 10.1152/ajpcell.00292.2017 |
| 通讯作者 | Ye, Shoudong(shdye@126.com) |
| 英文摘要 | Although long noncoding RNAs (lncRNAs) are emerging as new modulators in the fate deeision of pi impotent stem cells, the functions of specific lncRNAs remain unclear. Here, we found that telomeric RNA (TERRA or TelRNA), one type of lncRNAs, is highly expressed in mouse embryonic stem cells (mESCs) but declines significantly upon differentiation. TERRA is induced by the Wnt/beta-catenin signaling pathway and can reproduce its self-renewal-promoting effect when overexpressed. Further studies revealed that T cell factor 3 (TCF3) is a potential downstream target of TERRA and mediates the effect of TERRA in mESC maintenance. TERRA inhibits TCF3 transcription, while enforced TCF3 expression abrogates the undifferentiated state of mESCs supported by TERRA. Accordingly, the transcripts of the pluripotency genes Esrrb, Tfcp2l1, and Klf2, repressed by TCF3 in mESCs, are increased in TERRA -overexpressing cells. Our study therefore highlights the important role of TERRA in mESC maintenance and also uncovers a mechanism by which TERRA promotes self-renewal. These data will expand our understanding of the pluripotent regulatory network of ESCs. |
| WOS关键词 | REPEAT-CONTAINING RNA ; PLURIPOTENCY NETWORK ; REGULATORY CIRCUITRY ; DIFFERENTIATION ; TERRA ; MICRORNAS ; MAINTAINS ; TRANSCRIPTION ; EXPRESSION ; REPRESSION |
| 资助项目 | Natural Science Foundation of China[31671535] ; Natural Science Foundation of China[B020702] ; Natural Science Foundation of Anhui Province[1508085SQC204] ; Scientific Research Startup Fund of Anhui University[J01006068] |
| WOS研究方向 | Cell Biology ; Physiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000441181200007 |
| 出版者 | AMER PHYSIOLOGICAL SOC |
| 资助机构 | Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University ; Scientific Research Startup Fund of Anhui University |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/37787]  |
| 专题 | 合肥物质科学研究院_中科院强磁场科学中心 |
| 通讯作者 | Ye, Shoudong |
| 作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei, Anhui, Peoples R China 2.Univ Sci & Technol China, Hefei, Anhui, Peoples R China 3.Anhui Univ, Sch Life Sci, Ctr Stem Cell & Translat Med, 111 Jiu Long Rd, Hefei 230601, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Xiaojuan,Guo, Mengmeng,Zhang, Na,et al. Telomeric noncoding RNA promotes mouse embryonic stem cell self-renewal through inhibition of TCF3 activity[J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY,2018,314(6):C712-C720. |
| APA | Xu, Xiaojuan,Guo, Mengmeng,Zhang, Na,&Ye, Shoudong.(2018).Telomeric noncoding RNA promotes mouse embryonic stem cell self-renewal through inhibition of TCF3 activity.AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY,314(6),C712-C720. |
| MLA | Xu, Xiaojuan,et al."Telomeric noncoding RNA promotes mouse embryonic stem cell self-renewal through inhibition of TCF3 activity".AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 314.6(2018):C712-C720. |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。