中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
  4. 中科院强磁场科学中心
Core-Shell Structurized Fe3O4@C@MnO2 Nanoparticles as pH Responsive T-1-T-2* Dual-Modal Contrast Agents for Tumor Diagnosis

文献类型：期刊论文

作者Duan, Beichen1; Wang, Dongdong1; Wu, Huihui3; Xu, Pengping1; Jiang, Peng1; Xia, Guoliang1; Liu, Zhenbang3; Wang, Haibao4; Guo, Zhen3; Chen, Qianwang1,2
刊名ACS BIOMATERIALS SCIENCE & ENGINEERING
出版日期2018-08-01
卷号4期号:8页码:3047-3054
关键词MRI contrast agent dual-modal pH-responsive Fe3O4@C@MnO2
ISSN号2373-9878
DOI10.1021/acsbiomaterials.8b00287
通讯作者Wang, Haibao(whblgh@mail.ustc.edu.cn) ; Guo, Zhen(zhenguo@ustc.edu.cn) ; Chen, Qianwang(cqw@ustc.edu.cn)
英文摘要Biocompatible core shell Fe3O4@C@MnO2 nanopartides (named as FOCMO NPs) with an average size at 130 nm prepared through an effortless yet efficient strategy were employed as pH-activatable T-1-T-2* dual-modality magnetic resonance imaging (MRI) contrast agents (CAs). The release rate of Mn ions in acidic PBS (pH = 5.0) was approximately 10 times to that under condition with pH value of 7.4. Benefiting from excellent acid responsiveness, which facilitates the release of ions from FOCMO NPs at tumor region with acidic microenvironment and organelles, the diagnosis accuracy was commendably improved. After intravenous injection of FOCMO NPs, an efficiently intensive contrast in tumors are realized with a distinct enhancement of 127% in T-1 MRI signal 24 h after the administration. Moreover, a significant decreasement of 71% is witnessed in T-2 MRI signal. Those demonstrated that FOCMO NPs can achieve the purpose of positive/negative MRI simultaneously. Furthermore, obtained FOCMO NPs showed great hemocompatibility and negligible toxicity.
WOS关键词IRON-OXIDE NANOPARTICLES ; IMAGING PROBES ; THERAPY ; HYBRID ; SUPERCAPACITORS ; NANOCRYSTALS ; NANOTUBE ; ALBUMIN ; MN(II) ; T-1
资助项目National Natural Science Foundation of China[21571168] ; Most[2016YFA0101202] ; Most[U1232211] ; Most[31471268] ; National Key R&D Program of China[2016YFA0401801]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000441852000035
出版者AMER CHEMICAL SOC
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; Most ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/38085]  
专题合肥物质科学研究院_中科院强磁场科学中心
通讯作者Wang, Haibao; Guo, Zhen; Chen, Qianwang
作者单位1.Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Dept Mat Sci & Engn, 96 JinZhai Rd, Hefei 230026, Anhui, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China
3.Univ Sci & Technol China, Anhui Key Lab Cellular Dynam & Chem Biol, Sch Life Sci, 96 JinZhai Rd, Hefei 230027, Anhui, Peoples R China
4.Anhui Med Univ, Affiliated Hosp 1, Radiol Dept, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Duan, Beichen,Wang, Dongdong,Wu, Huihui,et al. Core-Shell Structurized Fe3O4@C@MnO2 Nanoparticles as pH Responsive T-1-T-2* Dual-Modal Contrast Agents for Tumor Diagnosis[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2018,4(8):3047-3054.
APA Duan, Beichen.,Wang, Dongdong.,Wu, Huihui.,Xu, Pengping.,Jiang, Peng.,...&Chen, Qianwang.(2018).Core-Shell Structurized Fe3O4@C@MnO2 Nanoparticles as pH Responsive T-1-T-2* Dual-Modal Contrast Agents for Tumor Diagnosis.ACS BIOMATERIALS SCIENCE & ENGINEERING,4(8),3047-3054.
MLA Duan, Beichen,et al."Core-Shell Structurized Fe3O4@C@MnO2 Nanoparticles as pH Responsive T-1-T-2* Dual-Modal Contrast Agents for Tumor Diagnosis".ACS BIOMATERIALS SCIENCE & ENGINEERING 4.8(2018):3047-3054.

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。