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Combined effects of co-exposure to formaldehyde and acrolein mixtures on cytotoxicity and genotoxicity in vitro

文献类型：期刊论文

作者Zhang, Sen1,2,3; Chen, Huan3; Wang, An1; Liu, Yong1; Hou, Hongwei3; Hu, Qingyuan3
刊名ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
出版日期2018-09-01
卷号25期号:25页码:25306-25314
关键词Formaldehyde Acrolein Genotoxicity Cytotoxicity Combined effects
ISSN号0944-1344
DOI10.1007/s11356-018-2584-z
通讯作者Hou, Hongwei(qsfctc@163.com) ; Hu, Qingyuan(huqy1965@163.com)
英文摘要FA (formaldehyde) and ACR (acrolein) are common pollutants in environment, which often occur together in air. So, adverse health effects may not only result from their individual toxicity but also from the combined toxicity. While often studied alone, combination effects of these pollutants are inconclusive. Here, we examined the combined cytotoxicity and genotoxicity of FA and ACR on A549 cells based on CCK-8 assay, comet assay, and cytokinesis-block micronuclei assay. FA and ACR mixtures showed significant cytotoxicity and genotoxicity even at NOECs (no observed effect concentrations). Moreover, FA and ACR administrated jointly at doses from NOECs to sub-cytotoxic concentrations demonstrated significant interactions in cytotoxicity, DNA strand breaks, and chromosome damage. Co-exposure to FA and ACR significantly showed a lower responses on DNA strand break and chromosome damage than those expected for additivity, while an opposite result was obtained on cytotoxicity. Taken together, these results indicated that there was significant interactions on cytotoxicity and genotoxicity for FA and ACR, and prolonged exposure to mixtures of FA and ACR below sub-cytotoxic concentrations can produce a serious threat in human's health.
WOS关键词PROTEIN CROSS-LINKING ; INDUCED DNA-DAMAGE ; MOLECULAR-MECHANISMS ; CHEMICAL-MIXTURES ; EPITHELIAL-CELLS ; CIGARETTE-SMOKE ; REPAIR ; INHIBITION ; OCHRATOXIN ; RELEVANCE
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000443012600063
出版者SPRINGER HEIDELBERG
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/37837]  
专题合肥物质科学研究院_应用技术研究所
通讯作者Hou, Hongwei; Hu, Qingyuan
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Appl Technol, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China
3.China Natl Tobacco Qual Supervis & Test Ctr, Zhengzhou 450001, Henan, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Sen,Chen, Huan,Wang, An,et al. Combined effects of co-exposure to formaldehyde and acrolein mixtures on cytotoxicity and genotoxicity in vitro[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2018,25(25):25306-25314.
APA Zhang, Sen,Chen, Huan,Wang, An,Liu, Yong,Hou, Hongwei,&Hu, Qingyuan.(2018).Combined effects of co-exposure to formaldehyde and acrolein mixtures on cytotoxicity and genotoxicity in vitro.ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,25(25),25306-25314.
MLA Zhang, Sen,et al."Combined effects of co-exposure to formaldehyde and acrolein mixtures on cytotoxicity and genotoxicity in vitro".ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 25.25(2018):25306-25314.

入库方式： OAI收割

来源：合肥物质科学研究院

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