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A simulation study of a dual-plate in-room PET system for dose verification in carbon ion therapy

文献类型：期刊论文

作者Chen, Z1,2; Hu, ZG1; Chen, JD1; Zhang, XL1; Guo, ZY1; Xiao, GQ1; Sun, ZY1; Huang, WX1; Wang, JS1; Chen, Z (reprint author), Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China.
刊名CHINESE PHYSICS C
出版日期2014
卷号38页码:088202
关键词Hadron Therapy Pet Gate Simulation
ISSN号1674-1137
DOI10.1088/1674-1137/38/8/088202
英文摘要During carbon ion therapy, lots of positron emitters such as C-11, O-15, C-15 are generated in irradiated tissues by nuclear reactions, and can be used to track the carbon beam in the tissue by a positron emission tomography (PET) scanner. In this study, an dual-plate in-room PET scanner has been designed and evaluated based on the GATE simulation platform to monitor patient dose in carbon ion therapy. The dual-plate PET is designed to avoid interference with the carbon beamline and with patient positioning. Its performance was compared with that of four-head and full-ring PET scanners. The dual-plate, four-head and full-ring PET scanners consisted of 30, 60, 60 detector modules, respectively, with a 36 cm distance between directly opposite detector modules for dose deposition measurements. Each detector module consisted of a 24 x 24 array of 2 mm x 2 mm x 18 mm LYSO pixels coupled to a Hamamatsu H8500 PMT. To estimate the production yield of positron emitters, a 10 cm x 15 cm x 15 cm cuboid PMMA phantom was irradiated with 172, 200, 250 MeV/u C-12 beams. 3D images of the activity distribution measured by the three types of scanner are produced by an iterative reconstruction algorithm. By comparing the longitudinal profile of positron emitters along the carbon beam path, it is indicated that use of the dual-plate PET scanner is feasible for monitoring the dose distribution in carbon ion therapy.
WOS关键词RADIOTHERAPY ; PROTON
资助项目Youth Innovation Promotion Association, CAS[201330YQO]
WOS研究方向Physics
语种英语
WOS记录号WOS:000340350200022
出版者CHINESE PHYSICAL SOC
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; West Light Foundation of the Chinese Academy of Sciences ; West Light Foundation of the Chinese Academy of Sciences ; National Major Scientific Instruments and Equipment Development Projects ; National Major Scientific Instruments and Equipment Development Projects ; Youth Innovation Promotion Association, CAS ; Youth Innovation Promotion Association, CAS
源URL[http://ir.impcas.ac.cn/handle/113462/23388]  
专题近代物理研究所_实验物理中心
近代物理研究所_兰州重离子研究装置
中国科学院近代物理研究所
通讯作者Chen, Z (reprint author), Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Z,Hu, ZG,Chen, JD,et al. A simulation study of a dual-plate in-room PET system for dose verification in carbon ion therapy[J]. CHINESE PHYSICS C,2014,38:088202.
APA Chen, Z.,Hu, ZG.,Chen, JD.,Zhang, XL.,Guo, ZY.,...&Chen, Z .(2014).A simulation study of a dual-plate in-room PET system for dose verification in carbon ion therapy.CHINESE PHYSICS C,38,088202.
MLA Chen, Z,et al."A simulation study of a dual-plate in-room PET system for dose verification in carbon ion therapy".CHINESE PHYSICS C 38(2014):088202.

入库方式： OAI收割

来源：近代物理研究所

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