The LET spectra at different penetration depths along secondary C-9 and C-11 beams
文献类型：期刊论文
| 作者 | Li, Q; Komori, M; Kanai, T; Kitagawa, A; Urakabe, E; Kanazawa, M; Tomitani, T; Sato, S |
| 刊名 | PHYSICS IN MEDICINE AND BIOLOGY
 |
| 出版日期 | 2004-11-21 |
| 卷号 | 49页码:5119-5133 |
| ISSN号 | 0031-9155 |
| DOI | 10.1088/0031-9155/49/22/007 |
| 英文摘要 | Owing to the potentially therapeutic enhancement of delayed particles in treating malignant diseases by radioactive C-9-ion beam, LET spectra at different penetration depths for a C-9 beam with 5% momentum spread, produced in the secondary beam line (SBL) at HIMAC, were measured with a multi-wire parallel-plate proportional counter. To compare these LET spectra with those of a therapeutic C-12 beam under similar conditions, the C-12 beam was replaced with an C-11 beam, yielded in the SBL as well and having almost the same range as that of the C-9 beam. The LET spectra of the T beam and its counterpart, i.e. the C-11 beam, at various depths were compared, especially around the Bragg peak regions. The results show that nearby the Bragg peak lower LET components decreased in the LET spectra of the C-9 beam while extra components between the LET peak caused by the primary beam and the lower components due to the fragments could be observed. These additional contributions in the LET spectra could be attributed to parts of the emitted particles from the radioactive C-9 ions with suitable conditions regarding the LET counter. Integrating these LET spectra in different manners, depth-dose and dose-averaged LET distributions were obtained for the C-9 and C-11 beams, forming the basic data sets for further studies. In general, the depth-dose distributions of the C-9 and C-11 beams are comparative, i.e. almost the same peak-to-plateau ratio. The ratio for the C-9 beam, however, has room to increase due to the geometric structure limitation of the present detector. The dose-averaged LETs along the beam penetration are always lower for the C-9 beam than for the C-11 beam except at the falloff region beyond the Bragg peak. Applying the present depth-dose and dose-averaged LET data sets as well as the essential radiobiological parameters obtained with C-12 beams previously for HSG cells, an estimate concerning the HSG cell surviving effects along the penetration of the C-9 and C-11 beams shows that lower survival fractions for the C-9 beam at the distal part of the Bragg peak, corresponding to the stopping region of the incoming C-9 ions, can be expected when the same entrance dose is given. It is still hard to appreciate the potential of C-9 beams in cancer therapy based on the present LET spectrum measurement, but it provides a substantial basis for upcoming radiobiological experiments. |
| WOS关键词 | HEAVY-ION RADIOTHERAPY ; LOW-ENERGY PROTONS ; PARTICLE DECAY BEAM ; V79 CELLS ; IRRADIATION SYSTEM ; CANCER-THERAPY ; INACTIVATION ; HIMAC ; RADIATIONS ; INDUCTION |
| WOS研究方向 | Engineering ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000225629200007 |
| 出版者 | IOP PUBLISHING LTD |
| 源URL | [http://119.78.100.186/handle/113462/24769]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Li, Q |
| 作者单位 | 1.Natl Inst Radiol Sci, Dept Phys Med, Res Ctr Charged Particle Therapy, Inage Ku, Chiba 2638555, Japan 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 3.Natl Inst Radiol Sci, Dept Accelerator Phys & Engn, Inage Ku, Chiba 2638555, Japan |
| 推荐引用方式 GB/T 7714 | Li, Q,Komori, M,Kanai, T,et al. The LET spectra at different penetration depths along secondary C-9 and C-11 beams[J]. PHYSICS IN MEDICINE AND BIOLOGY,2004,49:5119-5133. |
| APA | Li, Q.,Komori, M.,Kanai, T.,Kitagawa, A.,Urakabe, E.,...&Sato, S.(2004).The LET spectra at different penetration depths along secondary C-9 and C-11 beams.PHYSICS IN MEDICINE AND BIOLOGY,49,5119-5133. |
| MLA | Li, Q,et al."The LET spectra at different penetration depths along secondary C-9 and C-11 beams".PHYSICS IN MEDICINE AND BIOLOGY 49(2004):5119-5133. |
入库方式： OAI收割
来源：近代物理研究所
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