Comparative study on radiosensitivity of various tumor cells and human normal liver cells
文献类型：期刊论文
| 作者 | Yang, Jian-She1; Li, Wen-Jian; Zhou, Guang-Ming; Jin, Xiao-Dong; Xia, Jing-Guang; Wang, Ju-Fang; Wang, Zhuan-Zi; Guo, Chuan-Ling; Gao, Qing-Xiang2 |
| 刊名 | WORLD JOURNAL OF GASTROENTEROLOGY
 |
| 出版日期 | 2005-07-14 |
| 卷号 | 11页码:4098-4101 |
| 关键词 | Radiosensitivity Tumor cells Normal Liver cells |
| ISSN号 | 1007-9327 |
| 英文摘要 | AIM: To investigate the radiation response of various human tumor cells and normal liver cells. METHODS: Cell lines of human hepatoma cells (SMMC-7721), liver cells (L02), melanoma cells (A375) and cervical tumor (HeLa) were irradiated with Co-60 gamma-rays. Cell survive was documented by a colony assay. Chromatid breaks were measured by counting the number of chromatid breaks and isochromatid breaks immediately after prematurely chromosome condensed by Calyculin-A. RESULTS: Linear quadratic survival curve was observed in all of four cell lines, and dose-dependent increase in radiation-induced chromatid and isochromatid breaks were observed in GB2B phase. Among these four cell lines, A375 was most sensitive to radiation, while, L02 had the lowest radiosensitivity. For normal liver cells, chromatid breaks were easy to be repaired, isochromatid breaks were difficult to be repaired. CONCLUSION: The results suggest that the gamma-rays induced chromatid breaks can be possibly used as a good predictor of radiosensitivity, also, unrejoined isochromatid breaks probably tightly related with cell cancerization. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved. |
| 资助项目 | National Natural Science Foundation of China[10335050] ; Ministry of Science and Technology of the People's Republic of China[2003CCB00200] |
| WOS研究方向 | Gastroenterology & Hepatology |
| 语种 | 英语 |
| WOS记录号 | WOS:000208317700021 |
| 出版者 | BAISHIDENG PUBL GRP CO LTD |
| 资助机构 | National Natural Science Foundation of China ; Ministry of Science and Technology of the People's Republic of China |
| 源URL | [http://119.78.100.186/handle/113462/25031]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Yang, Jian-She |
| 作者单位 | 1.Chinese Acad Sci, Radiobiol Lab, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 2.Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Jian-She,Li, Wen-Jian,Zhou, Guang-Ming,et al. Comparative study on radiosensitivity of various tumor cells and human normal liver cells[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2005,11:4098-4101. |
| APA | Yang, Jian-She.,Li, Wen-Jian.,Zhou, Guang-Ming.,Jin, Xiao-Dong.,Xia, Jing-Guang.,...&Gao, Qing-Xiang.(2005).Comparative study on radiosensitivity of various tumor cells and human normal liver cells.WORLD JOURNAL OF GASTROENTEROLOGY,11,4098-4101. |
| MLA | Yang, Jian-She,et al."Comparative study on radiosensitivity of various tumor cells and human normal liver cells".WORLD JOURNAL OF GASTROENTEROLOGY 11(2005):4098-4101. |
入库方式： OAI收割
来源：近代物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。