A feasibility study of a prototype PET insert device to convert a general-purpose animal PET scanner to higher resolution
文献类型：期刊论文
| 作者 | Wu, Heyu1,2; Pa, Debashish3; O'Sullivan, Joseph A.4; Tai, Yuan-Chuan1 |
| 刊名 | JOURNAL OF NUCLEAR MEDICINE
 |
| 出版日期 | 2008 |
| 卷号 | 49页码:79-87 |
| 关键词 | small-animal PET high-resolution PET PET insert animal imaging |
| ISSN号 | 0161-5505 |
| DOI | 10.2967/jnumed.107.044149 |
| 英文摘要 | We developed a prototype system to evaluate the feasibility of using a PET insert device to achieve higher resolution from a general-purpose animal PET scanner. Methods:The system consists of a high-resolution PET detector, a computer-controlled rotation stage, and a custom mounting plate. The detector consists of a cerium-doped lutetium oxyorthosilicate array (12 x 12 crystals, 0.8 x 1.66 x 3.75 mm(3) each) directly coupled to a position-sensitive photomultiplier tube (PS-PMT). The detector signals were fed into the scanner electronics to establish coincidences between the 2 systems. The detector was mounted to a rotation stage that is attached to the scanner via the custom mounting plate after removing the transmission source holder. The rotation stage was concentric with the center of the scanner. The angular offset of the insert detector was calibrated via optimizing point-source images. In all imaging experiments, coincidence data were collected from 9 angles to provide 1800 sampling. A Na-22 point source was imaged at different offsets from the center to characterize the in-plane resolution of the insert system. A Ge-68 point source was stepped across the axial field of view to measure the sensitivity of the system. A 23.2-g mouse was injected with 38.5 MBq of F-18-fluoride and imaged at 3 h after injection for 2 h. Results: The transverse image resolution of the PET insert device ranges from 1.1- to 1.4-mm full width at half maximum (FWHM) without correction for the point-source dimension. This corresponds to approximately 33% improvement over the resolution of the original scanner (1.7- to 1.8-mm FWHM) in 2 of the 3 directions. The sensitivity of the device is 0.064% at the center of the field, 46-fold lower than the sensitivity of an existing animal PET scanner. The mouse bone scan had improved image resolution using the PET insert device over that of the existing animal PET scanner alone. Conclusion: We have demonstrated the feasibility of using a high-resolution insert device in an existing PET scanner to provide high-resolution PET. A PET insert device with more detector modules will improve sensitivity and may become an alternative to special-purpose PET systems for high-resolution PET. |
| WOS关键词 | POSITRON EMISSION TOMOGRAPH ; IMAGING SMALL ANIMALS ; SUBMILLIMETER-RESOLUTION ; MICROPET SCANNER ; DESIGN ; PERFORMANCE ; SYSTEM ; ALGORITHMS ; CRYSTALS |
| 资助项目 | NCI NIH HHS[R33-CA11011] ; NCI NIH HHS[R24-CA83060] |
| WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000252391700020 |
| 出版者 | SOC NUCLEAR MEDICINE INC |
| 源URL | [http://119.78.100.186/handle/113462/29646]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Tai, Yuan-Chuan |
| 作者单位 | 1.Washington Univ, Sch Med, Edward Mallinckrodt Inst Radiol, St Louis, MO 63110 USA 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China 3.Washington Univ, Dept Biomed Engn, St Louis, MO USA 4.Washington Univ, Dept Elect & Syst Engn, St Louis, MO USA |
| 推荐引用方式 GB/T 7714 | Wu, Heyu,Pa, Debashish,O'Sullivan, Joseph A.,et al. A feasibility study of a prototype PET insert device to convert a general-purpose animal PET scanner to higher resolution[J]. JOURNAL OF NUCLEAR MEDICINE,2008,49:79-87. |
| APA | Wu, Heyu,Pa, Debashish,O'Sullivan, Joseph A.,&Tai, Yuan-Chuan.(2008).A feasibility study of a prototype PET insert device to convert a general-purpose animal PET scanner to higher resolution.JOURNAL OF NUCLEAR MEDICINE,49,79-87. |
| MLA | Wu, Heyu,et al."A feasibility study of a prototype PET insert device to convert a general-purpose animal PET scanner to higher resolution".JOURNAL OF NUCLEAR MEDICINE 49(2008):79-87. |
入库方式： OAI收割
来源：近代物理研究所
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