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Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein Networks

文献类型：期刊论文

作者Liu, Hongrong1,2,3; Jin, Lei1,2; Koh, Sok Boon S.4; Atanasov, Ivo2; Schein, Stan2,5,6; Wu, Lily2,4; Zhou, Z. Hong1,2
刊名SCIENCE
出版日期2010-08-27
卷号329页码:1038-1043
ISSN号0036-8075
DOI10.1126/science.1187433
英文摘要Construction of a complex virus may involve a hierarchy of assembly elements. Here, we report the structure of the whole human adenovirus virion at 3.6 angstroms resolution by cryo-electron microscopy (cryo-EM), revealing in situ atomic models of three minor capsid proteins (IIIa, VIII, and IX), extensions of the (penton base and hexon) major capsid proteins, and interactions within three protein-protein networks. One network is mediated by protein IIIa at the vertices, within group-of-six (GOS) tiles-a penton base and its five surrounding hexons. Another is mediated by ropes (protein IX) that lash hexons together to form group-of-nine (GON) tiles and bind GONs to GONs. The third, mediated by IIIa and VIII, binds each GOS to five surrounding GONs. Optimization of adenovirus for cancer and gene therapy could target these networks.
WOS关键词CRYOELECTRON MICROSCOPY STRUCTURE ; RESOLUTION ; HEXON ; VECTORS ; TYPE-2 ; DNA ; IX ; BACTERIOPHAGE-PRD1 ; VISUALIZATION ; ORGANIZATION
资助项目National Institutes of Health[GM071940] ; National Institutes of Health[AI069015] ; National Institutes of Health[CA101904] ; National Institutes of Health[1S10RR23057] ; National Natural Scientific Foundation of China[10874144] ; Congressionally Directed Medical Research Programs[W81XWH-06-1-055]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000281253500030
出版者AMER ASSOC ADVANCEMENT SCIENCE
资助机构National Institutes of Health ; National Natural Scientific Foundation of China ; Congressionally Directed Medical Research Programs
源URL[http://119.78.100.186/handle/113462/32868]  
专题中国科学院近代物理研究所
通讯作者Zhou, Z. Hong
作者单位1.Univ Calif Los Angeles, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90095 USA
2.Univ Calif Los Angeles, Calif Nanosyst Inst, Los Angeles, CA 90095 USA
3.Xiangtan Univ, Inst Modern Phys, Xiangtan 411105, Hunan, Peoples R China
4.Univ Calif Los Angeles, Sch Med, Inst Mol Med IMED, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
5.Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA
6.Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90095 USA
推荐引用方式
GB/T 7714		 Liu, Hongrong,Jin, Lei,Koh, Sok Boon S.,et al. Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein Networks[J]. SCIENCE,2010,329:1038-1043.
APA Liu, Hongrong.,Jin, Lei.,Koh, Sok Boon S..,Atanasov, Ivo.,Schein, Stan.,...&Zhou, Z. Hong.(2010).Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein Networks.SCIENCE,329,1038-1043.
MLA Liu, Hongrong,et al."Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein Networks".SCIENCE 329(2010):1038-1043.

入库方式： OAI收割

来源：近代物理研究所

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