Chromosomal aberrations in the bone marrow cells of mice induced by accelerated C-12(6+) ions
文献类型：期刊论文
| 作者 | Ma, Xiaofei1,2,3,4,5; Zhang, Hong1,3,4; Wang, Zhenhua1,3,4; Min, Xianhua1,3,4; Liu, Yang1,3,4; Wu, Zhenhua1,3,4; Sun, Chao1,3,4,5; Hu, Bitao2 |
| 刊名 | MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
 |
| 出版日期 | 2011-11-01 |
| 卷号 | 716页码:20-26 |
| 关键词 | C-12(6+) ion Chromosomal aberration Bone marrow |
| ISSN号 | 0027-5107 |
| DOI | 10.1016/j.mrfmmm.2011.07.016 |
| 英文摘要 | The whole bodies of 6-week-old male Kun-Ming mice were exposed to different doses of 120 ions or X-rays. Chromosomal aberrations of the bone marrow (gaps, terminal deletions and breaks, fragments, inter-chromosomal fusions and sister-chromatid union) were scored in metaphase 9 h after exposure, corresponding to cells exposed in the G(2)-phase of the first mitosis cycle. Dose-response relationships for the frequency of chromosomal aberrations were plotted both by linear and linear-quadratic equations. The data showed that there was a dose-related increase in the frequency of chromosomal aberrations in all treated groups compared to controls. Linear-quadratic equations were a good fit for both radiation types. The compound theory of dual radiation action was applied to decipher the bigger curvature (D-2) of the dose-response curves of X-rays compared to those of C-12(6+) ions. Different distributions of the five types of aberrations and different degrees of homogeneity were found between C-12(6+) ion and X-ray irradiation and the possible underlying mechanism for these phenomena were analyzed according to the differences in the spatial energy deposition of both types of radiation. (C) 2011 Elsevier B.V. All rights reserved. |
| WOS关键词 | DENSELY IONIZING-RADIATION ; MONTE-CARLO SIMULATIONS ; TERM SPACE-FLIGHTS ; BLOOD-LYMPHOCYTES ; HEAVY-IONS ; IN-VIVO ; ASTRONAUTS LYMPHOCYTES ; CYTOGENETIC DAMAGE ; LEUKEMIA RISK ; FE-56 IONS |
| 资助项目 | National Basic Research Program of China[2010CB834202] ; National Natural Science Foundation of China[10835011] ; Scientific Technology Research Projects of Gansu Province[0702NKDA045] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000296177500003 |
| 出版者 | ELSEVIER SCIENCE BV |
| 资助机构 | National Basic Research Program of China ; National Natural Science Foundation of China ; Scientific Technology Research Projects of Gansu Province |
| 源URL | [http://119.78.100.186/handle/113462/33369]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Dept Heavy Ion Radiat Biol & Med, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Key Lab Heavy Ion Radiat Med, Lanzhou 730000, Peoples R China 4.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China 5.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Xiaofei,Zhang, Hong,Wang, Zhenhua,et al. Chromosomal aberrations in the bone marrow cells of mice induced by accelerated C-12(6+) ions[J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,2011,716:20-26. |
| APA | Ma, Xiaofei.,Zhang, Hong.,Wang, Zhenhua.,Min, Xianhua.,Liu, Yang.,...&Hu, Bitao.(2011).Chromosomal aberrations in the bone marrow cells of mice induced by accelerated C-12(6+) ions.MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,716,20-26. |
| MLA | Ma, Xiaofei,et al."Chromosomal aberrations in the bone marrow cells of mice induced by accelerated C-12(6+) ions".MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 716(2011):20-26. |
入库方式： OAI收割
来源：近代物理研究所
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