Chromosomal aberrations induced by C-12(6+) heavy ion irradiation in spermatogonia and spermatocytes of mice
文献类型：期刊论文
| 作者 | Zhang, H; Zheng, RL; Wang, RY; Wei, ZQ; Li, WJ; Gao, QX; Chen, WQ; Wang, ZH; Han, GW; Liang, JP |
| 刊名 | MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
 |
| 出版日期 | 1998-02-26 |
| 卷号 | 398页码:27-31 |
| 关键词 | C-12(6+) heavy ion chromosomal aberration spermatogonium spermatocyte mouse |
| ISSN号 | 0027-5107 |
| 英文摘要 | The testes of Kun-Ming strain mice were radiated with different doses of C-12(6+) ion or Co-60 gamma-ray. Chromosomal aberrations induced in spermatogonia and spermatocytes were analyzed by the air-drying method. The relative biological effectiveness (RBE) of C-12(6+) ion was calculated with respect to Co-60 gamma-ray for the induction of chromosomal aberrations. The C-12(6+) ion and Co-60 gamma-ray dose-response relationships for chromosomal aberrations were plotted by linear quadratic models. The results showed that there was an increase in frequency of chromosomal aberrations in all the treated groups compared to controls. The RBE values were 1.67 for aberrations of spermatogonia and 1.66 for aberrations of spermatocytes for a dose of 2.0 Gy. Moreover, a different distribution of the various types of aberrations has been found for C-12(6+) ion and Co-60 gamma-ray irradiations. The dose-response relationships for C-12(6+) ion and Co-60 gamma-ray exhibited negative curvature in both spermatogonia and spermatocytes groups: the frequencies of aberrations increased sharply at low doses and exhibited less sharp increases for higher doses, which may be related to an interaction between the chromosomal damage and a block in cell cycle. Our results may provide useful information for the assessment of genetic risks of humans exposed to heavy ions. (C) 1998 Elsevier Science B.V. |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000073726200003 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.186/handle/113462/35417]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zheng, RL |
| 作者单位 | 1.Lanzhou Univ, Dept Biol, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Dept Applicat Heavy Ions, Lanzhou 730000, Peoples R China 3.Lanzhou Med Coll, First Hosp, Dept Gynecol & Obstet, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, H,Zheng, RL,Wang, RY,et al. Chromosomal aberrations induced by C-12(6+) heavy ion irradiation in spermatogonia and spermatocytes of mice[J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,1998,398:27-31. |
| APA | Zhang, H.,Zheng, RL.,Wang, RY.,Wei, ZQ.,Li, WJ.,...&Liang, JP.(1998).Chromosomal aberrations induced by C-12(6+) heavy ion irradiation in spermatogonia and spermatocytes of mice.MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS,398,27-31. |
| MLA | Zhang, H,et al."Chromosomal aberrations induced by C-12(6+) heavy ion irradiation in spermatogonia and spermatocytes of mice".MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 398(1998):27-31. |
入库方式： OAI收割
来源：近代物理研究所
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