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Toxicity of Graphene Quantum Dots in Zebrafish Embryo

文献类型：期刊论文

作者Wang Zhen Guo1; Zhou Rong2,3,4; Jiang Dan1; Song Jing E1; Xu Qian1; Si Jing2,3,4; Chen Yun Ping1; Zhou Xin2,3,4; Gan Lu2,3,4; Li Jian Zhen5
刊名BIOMEDICAL AND ENVIRONMENTAL SCIENCES
出版日期2015-05-01
卷号28页码:341-351
关键词Graphene quantum dots Zebrafish Embryo Developmental toxicity
ISSN号0895-3988
DOI10.3967/bes2015.048
英文摘要Objective To evaluate the bio-safety of graphene quantum dots (GQDs), we studied its effects on the embryonic development of zebrafish. Methods In vivo, biodistribution and the developmental toxicity of GQDs were investigated in embryonic zebrafish at exposure concentrations ranging from 12.5-200 mu g/mL for 4-96 h post-fertilization (hpf). The mortality, hatch rate, malformation, heart rate, GQDs uptake, spontaneous movement, and larval behavior were examined. Results The fluorescence of GQDs was mainly localized in the intestines and heart. As the exposure concentration increased, the hatch and heart rate decreased, accompanied by an increase in mortality. Exposure to a high level of GQDs (200 mu g/mL) resulted in various embryonic malformations including pericardial edema, vitelline cyst, bent spine, and bent tail. The spontaneous movement significantly decreased after exposure to GQDs at concentrations of 50, 100, and 200 mu g/mL. The larval behavior testing (visible light test) showed that the total swimming distance and speed decreased dose-dependently. Embryos exposed to 12.5 mu g/mL showed hyperactivity while exposure to higher concentrations (25, 50, 100, and 200 mu g/mL) caused remarkable hypoactivity in the light-dark test. Conclusion Low concentrations of GQDs were relatively non-toxic. However, GODs disrupt the progression of embryonic development at concentrations exceeding 50 mu g/mL.
WOS关键词WALLED CARBON NANOTUBES ; IN-VIVO ; BIOIMAGING APPLICATION ; DIOXIDE NANOPARTICLES ; ADULT ZEBRAFISH ; OXIDE ; MODEL ; EXPOSURE ; PHOTOLUMINESCENCE ; CYTOTOXICITY
资助项目Key Program of the National Natural Science Foundation of China[U1432248] ; National Natural Science Foundation of China[11305226] ; National Natural Science Foundation of China[11175222]
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
语种英语
WOS记录号WOS:000359613900003
出版者CHINESE CENTER DISEASE CONTROL & PREVENTION
资助机构Key Program of the National Natural Science Foundation of China ; National Natural Science Foundation of China
源URL[http://119.78.100.186/handle/113462/40426]  
专题中国科学院近代物理研究所
通讯作者Zhang Hong
作者单位1.Lanzhou Univ, Sch Hosp Stomatol, Lanzhou 730000, Gansu, Peoples R China
2.Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Irradiat Med, Lanzhou 730000, Peoples R China
3.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China
4.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Gansu, Peoples R China
5.Northwest Normal Univ, Coll Life Sci, Lanzhou 730070, Gansu, Peoples R China
推荐引用方式
GB/T 7714		 Wang Zhen Guo,Zhou Rong,Jiang Dan,et al. Toxicity of Graphene Quantum Dots in Zebrafish Embryo[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2015,28:341-351.
APA Wang Zhen Guo.,Zhou Rong.,Jiang Dan.,Song Jing E.,Xu Qian.,...&Liu Bin.(2015).Toxicity of Graphene Quantum Dots in Zebrafish Embryo.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,28,341-351.
MLA Wang Zhen Guo,et al."Toxicity of Graphene Quantum Dots in Zebrafish Embryo".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 28(2015):341-351.

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来源：近代物理研究所

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