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Diallyl disulfide enhances carbon ion beams-induced apoptotic cell death in cervical cancer cells through regulating Tap73/Delta Np73

文献类型：期刊论文

作者Di, Cuixia1,2,3; Sun, Chao1,2,3; Li, Hongyan1,2,3; Si, Jing1,2,3; Zhang, Hong1,2,3; Han, Lu1,2,3; Zhao, Qiuyue1,2,3; Liu, Yang1,2,3; Liu, Bin4; Miao, Guoying1,2,3
刊名CELL CYCLE
出版日期2015-12-02
卷号14页码:3725-3733
关键词apoptosis cervical carcinoma Np73 Diallyl disulfide high-LET carbon beam Tap73 radiosensitivity
ISSN号1538-4101
DOI10.1080/15384101.2015.1104438
英文摘要Diallyl disulfide (DADS), extracted from crushed garlic by steam-distillation, has been reported to provide the anticancer activity in severalcancertypes. However,the effect of DADS on high-LET carbon beams - induced cell death remains unknown. Therefore, we used human cervical cancer cells to elucidate the molecular effects ofthis dallylsulfide. Radiotherapy remains the mainstay of treatment, especially in advanced cervical cancer and there is still space to improve the radiosensitivity to reduce radiation dosage. In this study, we found that radiation effects evoked by high-LET carbon beam was marked by inhibition of cell viability, cell cycle arrest, significant rise of apoptotic cells, regulation of transcription factor, such as p73, as well as alterations of crucial mediator of theapoptosispathway. We further demonstratedthat pretreatment of 10 mu M DADS in HeLa cells exposed to radiation resulted in decrease in cell viability and increased radiosensitivity. Additionally, cells pretreated with DADS obviously inhibited the radiation-induced G2/M phase arrest, but promoted radiation-induced apoptosis. Moreover, combination DADS and the radiation exacerbated the activation of apoptosis pathways through up-regulated ration of pro-apoptotic Tap73 to anti-apoptotic Np73, and its downstream proteins, such as FASLG, and APAF1. Taken together, these results suggest thatDADS is a potentialcandidate as radio sensitive agent for cervical cancer.
WOS关键词RADIATION-THERAPY ; SIGNALING PATHWAY ; PROSTATE-CANCER ; P73 ; EXPRESSION ; MECHANISMS ; GROWTH ; APAF1 ; PROLIFERATION ; RADIOTHERAPY
资助项目National Natural Science Foundation of China[U1432248] ; National Natural Science Foundation of China[11175222] ; National Natural Science Foundation of China[11205219] ; Chinese Academy of Sciences[Y260230XB0]
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000366450600013
出版者TAYLOR & FRANCIS INC
资助机构National Natural Science Foundation of China ; Chinese Academy of Sciences
源URL[http://119.78.100.186/handle/113462/41242]  
专题中国科学院近代物理研究所
通讯作者Zhang, Hong
作者单位1.Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou, Peoples R China
2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China
3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou, Peoples R China
4.Lanzhou Univ, Coll Stomatol, Lanzhou 730000, Peoples R China
推荐引用方式
GB/T 7714		 Di, Cuixia,Sun, Chao,Li, Hongyan,et al. Diallyl disulfide enhances carbon ion beams-induced apoptotic cell death in cervical cancer cells through regulating Tap73/Delta Np73[J]. CELL CYCLE,2015,14:3725-3733.
APA Di, Cuixia.,Sun, Chao.,Li, Hongyan.,Si, Jing.,Zhang, Hong.,...&Liu, Yuanyuan.(2015).Diallyl disulfide enhances carbon ion beams-induced apoptotic cell death in cervical cancer cells through regulating Tap73/Delta Np73.CELL CYCLE,14,3725-3733.
MLA Di, Cuixia,et al."Diallyl disulfide enhances carbon ion beams-induced apoptotic cell death in cervical cancer cells through regulating Tap73/Delta Np73".CELL CYCLE 14(2015):3725-3733.

入库方式： OAI收割

来源：近代物理研究所

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