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Synthesis of Luminescent Graphene Quantum Dots with High Quantum Yield and Their Toxicity Study

文献类型：期刊论文

作者Jiang, Dan1,2; Chen, Yunping1,2; Li, Na1; Li, Wen1; Wang, Zhenguo1,3; Zhu, Jingli1; Zhang, Hong3; Liu, Bin1; Xu, Shan2
刊名PLOS ONE
出版日期2015-12-28
卷号10页码:15
ISSN号1932-6203
DOI10.1371/journal.pone.0144906
英文摘要High fluorescence quantum yield graphene quantum dots (GQDs) have showed up as a new generation for bioimaging. In this work, luminescent GQDs were prepared by an ameliorative photo-Fenton reaction and a subsequent hydrothermal process using graphene oxide sheets as the precursor. The as-prepared GQDs were nanomaterials with size ranging from 2.3 to 6.4 nm and emitted intense green luminescence in water. The fluorescence quantum yield was as high as 24.6%(excited at 340 nm) and the fluorescence was strongest at pH 7. Moreover, the influences of low-concentration (12.5, 25 mu g/mL) GQDs on the morphology, viability, membrane integrity, internal cellular reactive oxygen species level and mortality of HeLa cells were relatively weak, and the in vitro imaging demonstrated GQDs were mainly in the cytoplasm region. More strikingly, zebrafish embryos were co-cultured with GQDs for in vivo imaging, and the results of heart rate test showed the intake of small amounts of GQDs brought little harm to the cardiovascular of zebrafish. GQDs with high quantum yield and strong photoluminescence show good biocompatibility, thus they show good promising for cell imaging, biolabeling and other biomedical applications.
WOS关键词ONE-STEP SYNTHESIS ; FUNCTIONALIZED GRAPHENE ; PHOTOVOLTAIC DEVICES ; CARBON NANOTUBES ; IN-VITRO ; OXIDE ; PHOTOLUMINESCENCE ; FLUORESCENT ; REDUCTION ; SINGLE
资助项目Nature Science Foundations of China[21103205]
WOS研究方向Science & Technology - Other Topics
语种英语
出版者PUBLIC LIBRARY SCIENCE
WOS记录号WOS:000367451400015
资助机构Nature Science Foundations of China
源URL[http://119.78.100.186/handle/113462/41332]  
专题中国科学院近代物理研究所
通讯作者Liu, Bin
作者单位1.Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China
2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select, Lanzhou 730000, Peoples R China
3.Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou, Peoples R China
推荐引用方式
GB/T 7714		 Jiang, Dan,Chen, Yunping,Li, Na,et al. Synthesis of Luminescent Graphene Quantum Dots with High Quantum Yield and Their Toxicity Study[J]. PLOS ONE,2015,10:15.
APA Jiang, Dan.,Chen, Yunping.,Li, Na.,Li, Wen.,Wang, Zhenguo.,...&Xu, Shan.(2015).Synthesis of Luminescent Graphene Quantum Dots with High Quantum Yield and Their Toxicity Study.PLOS ONE,10,15.
MLA Jiang, Dan,et al."Synthesis of Luminescent Graphene Quantum Dots with High Quantum Yield and Their Toxicity Study".PLOS ONE 10(2015):15.

入库方式： OAI收割

来源：近代物理研究所

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