The influence of non-DNA-targeted effects on carbon ion-induced low-dose hyper-radiosensitivity in MRC-5 cells
文献类型：期刊论文
| 作者 | Ye, Fei1,2,3,4 ; Ning, Jing5; Liu, Xinguo1,4; Jin, Xiaodong1,4; Wang, Tieshan2; Li, Qiang1,4
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| 刊名 | JOURNAL OF RADIATION RESEARCH
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| 出版日期 | 2016-03-01 |
| 卷号 | 57页码:103-109 |
| 关键词 | low-dose hyper-radiosensitivity non-DNA-targeted effect gap junctional intercellular communication carbon-ion radiation |
| ISSN号 | 0449-3060 |
| DOI | 10.1093/jrr/rrv072 |
| 英文摘要 | Low-dose hyper-radiosensitivity (LDHRS) is a hot topic in normal tissue radiation protection. However, the primary causes for LDHRS still remain unclear. In this study, the impact of non-DNA-targeted effects (NTEs) on high-LET radiation-induced LDHRS was investigated. Human normal lung fibroblast MRC-5 cells were irradiated with high-LET carbon ions, and low-dose biological effects (in terms of various bio-endpoints, including colony formation, DNA damage and micronuclei formation) were detected under conditions with and without gap junctional intercellular communication (GJIC) inhibition. LDHRS was observed when the radiation dose was <0.2 Gy for all bio-endpoints under investigation, but vanished when the GJIC was suppressed. Based on the probability of cells being hit and micro-dose per cell calculation, we deduced that the LDHRS phenomenon came from the combined action of direct hits and NTEs. We concluded that GJIC definitely plays an important role in cytotoxic substance spreading in high-LET carbon ion-induced LDHRS. |
| WOS关键词 | GAP-JUNCTION COMMUNICATION ; X-RAY MICROBEAM ; V79 CELLS ; 2ND CANCERS ; HEAVY-IONS ; RADIATION ; HYPERSENSITIVITY ; IRRADIATION ; IMPACT ; PROPAGATION |
| 资助项目 | National Natural Science Foundation of China[U1232207] ; National Natural Science Foundation of China[10905080] ; National Natural Science Foundation of China[11075191] ; National Natural Science Foundation of China[11205217] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000372619800001 |
| 出版者 | OXFORD UNIV PRESS |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://119.78.100.186/handle/113462/42076]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Li, Qiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Med Phys Div, Lanzhou 730000, Peoples R China 2.Lanzhou Univ, Dept Modern Phys, Lanzhou 730000, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 5.Gansu Prov Peoples Hosp, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Fei,Ning, Jing,Liu, Xinguo,et al. The influence of non-DNA-targeted effects on carbon ion-induced low-dose hyper-radiosensitivity in MRC-5 cells[J]. JOURNAL OF RADIATION RESEARCH,2016,57:103-109. |
| APA | Ye, Fei,Ning, Jing,Liu, Xinguo,Jin, Xiaodong,Wang, Tieshan,&Li, Qiang.(2016).The influence of non-DNA-targeted effects on carbon ion-induced low-dose hyper-radiosensitivity in MRC-5 cells.JOURNAL OF RADIATION RESEARCH,57,103-109. |
| MLA | Ye, Fei,et al."The influence of non-DNA-targeted effects on carbon ion-induced low-dose hyper-radiosensitivity in MRC-5 cells".JOURNAL OF RADIATION RESEARCH 57(2016):103-109. |
入库方式： OAI收割
来源：近代物理研究所
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