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miR-449a enhances radiosensitivity through modulating pRb/E2F1 in prostate cancer cells

文献类型：期刊论文

作者Mao, Aihong1,2,3,6; Liu, Yang1,4,5; Wang, Yali1,4,5; Zhao, Qiuyue1,4,5,6; Zhou, Xin1,4,5; Sun, Chao1,4,5; Di, Cuixia1,4,5; Si, Jing1,4,5; Gan, Lu1,4,5; Zhang, Hong1,4,5,7
刊名TUMOR BIOLOGY
出版日期2016-04-01
卷号37页码:4831-4840
关键词miR-449a G2/Marrest Apoptosis pRb/E2F1 Radiosensitivity Prostate cancer
ISSN号1010-4283
DOI10.1007/s13277-015-4336-8
英文摘要miR-449a, a novel tumor suppressor, is deregulated in various malignancies, including prostate cancer. Overexpression of miR-449a induces cell cycle arrest, apoptosis, and senescence, but its role in response to ionizing radiation and underlying molecular mechanism are still unknown. Here, we report that miR-449a enhances radiation-induced G2/M phase arrest and apoptosis through modulating pRb/E2F1 and sensitizes prostate cancer cells to X-ray radiation. In wild-type Rb PC-3 cells, overexpression of miR-449a enhances radiation-induced G2/M arrest and apoptosis and promotes the sensitivity to X-ray radiation. While mutant Rb DU-145 cells are resistant to the X-ray radiation despite in the presence of miR-449a. The cell cycle distribution of DU-145 cells is not significantly altered by miR-449a in the response to ionizing radiation. Furthermore, elevated miR-449a downregulates cell cycle regulator CDC25A and oncogene HDAC1. By targeting genes involved in controlling pRb/E2F1 activity, miR-449a regulates cell cycle progression and apoptosis and consequently enhances the radiosensitivity of PC-3 cells. Thus, miR-449a, as a miRNA component of the Rb pathway, promotes the radiosensitivity of PC-3 cells through regulating pRb/E2F1.
WOS关键词MUTANT P53 ALLELES ; RETINOBLASTOMA PROTEIN ; IONIZING-RADIATION ; CYCLE REGULATION ; CARCINOMA-CELLS ; MICRORNAS ; TARGETS ; ARREST ; APOPTOSIS ; PROLIFERATION
资助项目National Natural Science Foundation of China[U1432248] ; National Natural Science Foundation of China[11105203] ; National Natural Science Foundation of China[11405230] ; Scientific Technology Research Projects of Gansu Province[1107RJYA033]
WOS研究方向Oncology
语种英语
WOS记录号WOS:000374904500064
出版者SPRINGER
资助机构National Natural Science Foundation of China ; Scientific Technology Research Projects of Gansu Province
源URL[http://119.78.100.186/handle/113462/42445]  
专题中国科学院近代物理研究所
通讯作者Zhang, Hong
作者单位1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
2.Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Peoples R China
3.Inst Gansu Med Sci Res, Lanzhou 730050, Peoples R China
4.Chinese Acad Sci, Key Lab Heavy Ion Radiat Med, Lanzhou 730000, Peoples R China
5.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
7.Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, 509 Nanchang Rd, Lanzhou 730000, Peoples R China
推荐引用方式
GB/T 7714		 Mao, Aihong,Liu, Yang,Wang, Yali,et al. miR-449a enhances radiosensitivity through modulating pRb/E2F1 in prostate cancer cells[J]. TUMOR BIOLOGY,2016,37:4831-4840.
APA Mao, Aihong.,Liu, Yang.,Wang, Yali.,Zhao, Qiuyue.,Zhou, Xin.,...&Zhang, Hong.(2016).miR-449a enhances radiosensitivity through modulating pRb/E2F1 in prostate cancer cells.TUMOR BIOLOGY,37,4831-4840.
MLA Mao, Aihong,et al."miR-449a enhances radiosensitivity through modulating pRb/E2F1 in prostate cancer cells".TUMOR BIOLOGY 37(2016):4831-4840.

入库方式： OAI收割

来源：近代物理研究所

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