The biological effects induced by high-charged and energy particles and its application in cancer therapy
文献类型：期刊论文
| 作者 | Zhu, J.; Ren, Z.; Chen, Y.; Hu, B.1 |
| 刊名 | INTERNATIONAL JOURNAL OF RADIATION RESEARCH
 |
| 出版日期 | 2016 |
| 卷号 | 14页码:1-7 |
| 关键词 | HZE particles space radiation clustered DNA damage radiotherapy |
| ISSN号 | 2322-3243 |
| DOI | 10.7508/ijrr.2016.01.001 |
| 英文摘要 | The radiobiological effects of high atomic number and energy (HZE particles) ion beams are of interest for radioprotecon in space and tumor radiotherapy. Space radiaon mainly consists of heavy charged particles from protons to iron ions, which is distinct from common terrestrial forms of radiaon. HZE particles pose a significant cancer risk to astronauts on prolonged space missions. With high delivered energies and intense ionizaon, HZE particles can damage not only the biological systems but also the shielding materials. HZE particle are more effective than low-LET radiaon like gamma- or X-rays to induce genetic mutation and cancer. On Earth, similar ions are being used for targeted cancer therapy due to the advantage of the inverse dose profile, with delivering higher doses to the tumor while keeping lower doses to the surrounding tissues. In this review, we focus on the recent insights into the biological effects caused by HZE particle and the corresponding mechanism. We also discuss the current application of HZE particle in cancer therapy. Understanding the mechanisms underlying the repair of DNA damage induced by HZE particle contribute to accurately estimate the risks to human health associated with HZE particle exposure and to improve the effectiveness of tumor radiotherapy. |
| WOS关键词 | DOUBLE-STRAND BREAKS ; CLUSTERED DNA-DAMAGE ; CARBON ION RADIOTHERAPY ; BASE-EXCISION-REPAIR ; HUMAN FIBROBLASTS ; ESCHERICHIA-COLI ; MAMMALIAN-CELLS ; CHROMOSOME BREAKAGE ; IONIZING-RADIATION ; SPACE EXPLORATION |
| 资助项目 | National Natural Science Foundation of China[31170803] ; National Natural Science Foundation of China[U1432121] ; National Key Scientific Instrument and Equipment Development Project of China[2012YQ03014210] |
| WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000380177800001 |
| 出版者 | IJRR-IRANIAN JOURNAL RADIATION RES |
| 资助机构 | National Natural Science Foundation of China ; National Key Scientific Instrument and Equipment Development Project of China |
| 源URL | [http://119.78.100.186/handle/113462/43092]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Hu, B. |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Gansu Key Lab Space Radiobiol, Lanzhou 730000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, J.,Ren, Z.,Chen, Y.,et al. The biological effects induced by high-charged and energy particles and its application in cancer therapy[J]. INTERNATIONAL JOURNAL OF RADIATION RESEARCH,2016,14:1-7. |
| APA | Zhu, J.,Ren, Z.,Chen, Y.,&Hu, B..(2016).The biological effects induced by high-charged and energy particles and its application in cancer therapy.INTERNATIONAL JOURNAL OF RADIATION RESEARCH,14,1-7. |
| MLA | Zhu, J.,et al."The biological effects induced by high-charged and energy particles and its application in cancer therapy".INTERNATIONAL JOURNAL OF RADIATION RESEARCH 14(2016):1-7. |
入库方式： OAI收割
来源：近代物理研究所
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