The synergistic radiosensitizing effect of tirapazamine-conjugated gold nanoparticles on human hepatoma HepG2 cells under X-ray irradiation
文献类型：期刊论文
| 作者 | Liu, Xi1,2,3,4; Liu, Yan1,2,3,4 ; Zhang, Pengcheng1,2,3,4; Jin, Xiaodong1,2,3; Zheng, Xiaogang1,2,3,4; Ye, Fei1,2,3,4; Chen, Weiqiang1,2,3; Li, Qiang1,2,3
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| 刊名 | INTERNATIONAL JOURNAL OF NANOMEDICINE
 |
| 出版日期 | 2016 |
| 卷号 | 11页码:3517-3530 |
| 关键词 | AuNPs radiation enhancement synergistic effect human hepatoma cells hydroxyl radical production |
| ISSN号 | 1178-2013 |
| DOI | 10.2147/IJN.S105348 |
| 英文摘要 | Reductive drug-functionalized gold nanoparticles (AuNPs) have been proposed to enhance the damage of X-rays to cells through improving hydroxyl radical production by secondary electrons. In this work, polyethylene glycol-capped AuNPs were conjugated with tirapazamine (TPZ) moiety, and then thioctyl TPZ (TPZs)-modified AuNPs (TPZs-AuNPs) were synthesized. The TPZs-AuNPs were characterized by transmission electron microscopy, ultraviolet-visible spectra, dynamic light scattering, and inductively coupled plasma mass spectrometry to have a size of 16.6 +/- 2.1 nm in diameter and a TPZs/AuNPs ratio of similar to 700:1. In contrast with PEGylated AuNPs, the as-synthesized TPZs-AuNPs exhibited 20% increment in hydroxyl radical production in water at 2.0 Gy, and 19% increase in sensitizer enhancement ratio at 10% survival fraction for human hepatoma HepG2 cells under X-ray irradiation. The production of reactive oxygen species in HepG2 cells exposed to X-rays in vitro demonstrated a synergistic radiosensitizing effect of AuNPs and TPZ moiety. Thus, the reductive drug-conjugated TPZs-AuNPs as a kind of AuNP radiosensitizer with low gold loading provide a new strategy for enhancing the efficacy of radiation therapy. |
| WOS关键词 | RADIATION-THERAPY ; PARTICLE-SIZE ; ENHANCEMENT ; AGENTS ; DNA ; RADIOTHERAPY ; 1,4-DIOXIDE ; CLEAVAGE ; ASSAY ; MICE |
| 资助项目 | National Natural Science Foundation of China[U1232207] ; National Natural Science Foundation of China[11075191] ; National Natural Science Foundation of China[11205217] ; National Natural Science Foundation of China[11475231] ; National Key Technology Support Program[2015BA101B11] ; National key Research and Development Program of the Ministry of Science and Technology of China[2016YFC0904602] |
| WOS研究方向 | Science & Technology - Other Topics ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000380387400001 |
| 出版者 | DOVE MEDICAL PRESS LTD |
| 资助机构 | National Natural Science Foundation of China ; National Key Technology Support Program ; National key Research and Development Program of the Ministry of Science and Technology of China |
| 源URL | [http://119.78.100.186/handle/113462/43097]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Chen, Weiqiang; Li, Qiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou, Gansu, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Gansu, Peoples R China 3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Sch Life Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xi,Liu, Yan,Zhang, Pengcheng,et al. The synergistic radiosensitizing effect of tirapazamine-conjugated gold nanoparticles on human hepatoma HepG2 cells under X-ray irradiation[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2016,11:3517-3530. |
| APA | Liu, Xi.,Liu, Yan.,Zhang, Pengcheng.,Jin, Xiaodong.,Zheng, Xiaogang.,...&Li, Qiang.(2016).The synergistic radiosensitizing effect of tirapazamine-conjugated gold nanoparticles on human hepatoma HepG2 cells under X-ray irradiation.INTERNATIONAL JOURNAL OF NANOMEDICINE,11,3517-3530. |
| MLA | Liu, Xi,et al."The synergistic radiosensitizing effect of tirapazamine-conjugated gold nanoparticles on human hepatoma HepG2 cells under X-ray irradiation".INTERNATIONAL JOURNAL OF NANOMEDICINE 11(2016):3517-3530. |
入库方式： OAI收割
来源：近代物理研究所
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