4-isothiocyanate-2, 2, 6, 6-tetramethyl piperidinooxyl inhibits angiogenesis by suppressing VEGFR2 and Tie2 phosphorylation
文献类型：期刊论文
| 作者 | Liu, Yuanyuan1,2 ; Gao, Jing3; Huang, Shuangsheng3; Hu, Lamei1; Wang, Zhiqiang1; Wang, Zheyuan4; Chen, Xiao4; Zhang, Xiaoyu1; Li, Wenguang1
|
| 刊名 | ONCOLOGY LETTERS
 |
| 出版日期 | 2016-10-01 |
| 卷号 | 12页码:2828-2834 |
| 关键词 | 4-isothiocyanate-2 2 6 6-tetramethyl piperidinooxyl angiogenesis reactive oxygen species vascular endothelial growth factor receptor 2 Tie2 |
| ISSN号 | 1792-1074 |
| DOI | 10.3892/ol.2016.4948 |
| 英文摘要 | Reactive oxygen species (ROS) are involved in the signaling pathway and are triggered by angiogenic factors, including vascular endothelial growth factor and angiopoietins. 4-isothiocyanate-2, 2, 6, 6-tetramethyl piperidinooxyl (4-ISO-Tempo) is one of the nitroxides that exhibits antioxidant activity. However, the anti-angiogenic effect of 4-ISO-Tempo remains unknown. The aim of this study was to investigate the effect of 4-ISO-Tempo on tumor proliferation and angiogenesis as well as its underlying mechanisms. Our results revealed that 4-ISO-Tempo significantly inhibited the viability of neoplastic and endothelial cells. Furthermore, the effective concentration of 4-ISO-Tempo on human microvascular endothelial cell 1 (HMEC-1) was lower than that on human lung adenocarcinoma A549 and human colon cancer SW620 cells. This suggested that endothelial cells were more sensitive to 4-ISO-Tempo than tumor cells. Furthermore, we demonstrated that 4-ISO-Tempo also suppressed secretion of matrix metalloproteinase (MMP)-2 and MMP-9, and migration and tube formation of HMEC-1 cells. The mechanism is attributed to the decreasing ROS generation and further phosphorylation of vascular endothelial growth factor receptor 2 and Tie2. Our findings suggest that 4-ISO-Tempo should be investigated for its usefulness in anti-angiogenesis therapies. |
| WOS关键词 | ENDOTHELIAL GROWTH-FACTOR ; NADPH OXIDASE 4 ; SIGNALING PATHWAYS ; PROSTATE-CANCER ; DOWN-REGULATION ; TUMOR-GROWTH ; IN-VIVO ; EXPRESSION ; RECEPTORS ; CELLS |
| 资助项目 | Medical Foundation of Lanzhou University[LZUYX200617] ; Key Lab of Preclinical Study for New Drugs of Gansu Province[GSKFKT-0702] ; National Natural Science Foundation of China[30700142] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000385579200091 |
| 出版者 | SPANDIDOS PUBL LTD |
| 资助机构 | Medical Foundation of Lanzhou University ; Key Lab of Preclinical Study for New Drugs of Gansu Province ; National Natural Science Foundation of China |
| 源URL | [http://119.78.100.186/handle/113462/43475]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Li, Wenguang |
| 作者单位 | 1.Lanzhou Univ, Coll Basic Med, Key Lab Preclin Study New Drugs Gansu, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 3.Northwest Univ Nationalities, Clin Lab, Coll Med, Affiliated Hosp, Lanzhou 730030, Gansu, Peoples R China 4.Lanzhou Univ, Dept Gen Surg, Hosp 3, Lanzhou 730030, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yuanyuan,Gao, Jing,Huang, Shuangsheng,et al. 4-isothiocyanate-2, 2, 6, 6-tetramethyl piperidinooxyl inhibits angiogenesis by suppressing VEGFR2 and Tie2 phosphorylation[J]. ONCOLOGY LETTERS,2016,12:2828-2834. |
| APA | Liu, Yuanyuan.,Gao, Jing.,Huang, Shuangsheng.,Hu, Lamei.,Wang, Zhiqiang.,...&Li, Wenguang.(2016).4-isothiocyanate-2, 2, 6, 6-tetramethyl piperidinooxyl inhibits angiogenesis by suppressing VEGFR2 and Tie2 phosphorylation.ONCOLOGY LETTERS,12,2828-2834. |
| MLA | Liu, Yuanyuan,et al."4-isothiocyanate-2, 2, 6, 6-tetramethyl piperidinooxyl inhibits angiogenesis by suppressing VEGFR2 and Tie2 phosphorylation".ONCOLOGY LETTERS 12(2016):2828-2834. |
入库方式： OAI收割
来源：近代物理研究所
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