Fe-56 irradiation-induced cognitive deficits through oxidative stress in mice
文献类型：期刊论文
| 作者 | Yan, Jiawei1,2,3,4; Liu, Yang1,2,3 ; Zhao, Qiuyue1,2,3,4; Li, Jie5; Mao, Aihong1,2,3,4,6; Li, Hongyan1,2,3; Di, Cuixia1,2,3; Zhang, Hong1,2,3
|
| 刊名 | TOXICOLOGY RESEARCH
 |
| 出版日期 | 2016 |
| 卷号 | 5页码:1672-1679 |
| ISSN号 | 2045-452X |
| DOI | 10.1039/c6tx00282j |
| 英文摘要 | The rapid growth of manned space flight results in more concerns about health risks and an urgent need for health assessment for space travel. The cosmic environment is complicated and full of radiation. Because of their strong biological effects, heavy ions such as Fe-56 ions are considered to be an important component of these lethal galactic rays. Due to the importance of brain function to astronauts, we explored the long-term effects and potential mechanisms of Fe-56 ion radiation on mice brains containing the hippocampus. In our study, radiation doses were carried out with 0.5 Gy, 1 Gy or 2 Gy. One month after whole-body Fe-56 ion exposure, the Morris water maze test was performed to assess the ability of spatial learning and memory. A histological study was used for pathology analysis of the hippocampus. Alteration of oxidative stress was reflected by MDA and GSH and oxidative DNA damage marked by 8-OHdG was detected by biochemical and immunofluorescence methods. In our results, irradiated groups exhibited significant changes in behavioral performance and also showed loose and edematous arrangement in the pathological characteristics. Furthermore, whole brain levels of MDA, GSH and 8-OHdG increased in the irradiated groups. In addition, increased expression of 8-OHdG can also be detected by immunofluorescence in the hippocampus. Our findings revealed a linkage between radiation-induced oxidative stress and behavioral deficits. This may suggest an underlying mechanism of brain tissue protection and risk assessment in manned space flight. |
| WOS关键词 | DNA-DAMAGE ; IONIZING-RADIATION ; SPATIAL MEMORY ; GRANULE CELLS ; HEAVY-IONS ; WATER-MAZE ; HIPPOCAMPUS ; SPACE ; RATS ; BIOLOGY |
| 资助项目 | Key Program of National Natural Science Foundation of China[U1432248] ; National Key Projects of Research and Development[2016YFC0904600] ; National Natural Science Foundation of China[11305224] ; National Natural Science Foundation of China[11675234] ; Western Talent Program of Chinese Academy of Sciences[Y260230XB0] |
| WOS研究方向 | Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000387013300017 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | Key Program of National Natural Science Foundation of China ; National Key Projects of Research and Development ; National Natural Science Foundation of China ; Western Talent Program of Chinese Academy of Sciences |
| 源URL | [http://119.78.100.186/handle/113462/43604]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Med, Lanzhou 730000, Peoples R China 3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 5.Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Peoples R China 6.Inst Gansu Med Sci Res, Lanzhou 730050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Jiawei,Liu, Yang,Zhao, Qiuyue,et al. Fe-56 irradiation-induced cognitive deficits through oxidative stress in mice[J]. TOXICOLOGY RESEARCH,2016,5:1672-1679. |
| APA | Yan, Jiawei.,Liu, Yang.,Zhao, Qiuyue.,Li, Jie.,Mao, Aihong.,...&Zhang, Hong.(2016).Fe-56 irradiation-induced cognitive deficits through oxidative stress in mice.TOXICOLOGY RESEARCH,5,1672-1679. |
| MLA | Yan, Jiawei,et al."Fe-56 irradiation-induced cognitive deficits through oxidative stress in mice".TOXICOLOGY RESEARCH 5(2016):1672-1679. |
入库方式： OAI收割
来源：近代物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。