Xanthohumol induces paraptosis of leukemia cells through p38 mitogen activated protein kinase signaling pathway
文献类型：期刊论文
| 作者 | Mi, Xiangquan1,2; Wang, Chunming1; Sun, Chao3; Chen, Xu1; Huo, Xiang1; Zhang, Yiming2; Li, Gang2; Xu, Bo2; Zhang, Jun4; Xie, Jianxin4 |
| 刊名 | ONCOTARGET
 |
| 出版日期 | 2017-05-09 |
| 卷号 | 8页码:31297-31304 |
| 关键词 | xanthohumol paraptosis p38-MAPK cytoplasmic vacuolation ER stress |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.16185 |
| 英文摘要 | Xanthohumol as a natural polyphenol demonstrates an anticancer activity, but its underlying mechanism remains unclear. In this study, we showed that xanthohumol (XN) induces paraptosis of leukemia cells. The paraptosis is one cell death which is characterized by dilation of the endoplasmic reticulum and/or mitochondria. The results demonstrated that XN treatment significantly inhibited cell proliferation and triggered extensive cytoplasmic vacuolation of HL-60 leukemia cells, but it did not cause the cleavage of caspase-3 protein or apoptosis. In contrast, XN treatment resulted in LC3-II accumulation through blocking of autophagosome maturation. Interestingly, the induction of cytoplasmic vacuolization by XN is not associated with autophagy modulated by XN, therefore, XN-induced cell death of HL-60 leukemia cells is not the classical apoptotic cell death. Intriguingly, XN treatment triggered the dilatation of endoplasma reticulum (ER) and induced ER stress by upregulating C/EBP homologous protein and unfolded protein response regulator Grp78/Bip. Furthermore, XN treatment triggered p38 mitogen activated protein kinase and its specific inhibitor inhibited the paraptosis of HL-60 leukemia cells by XN. In conclusion, we for the first time demonstrated that XN treatment can induce paraptosis of leukemia cells through activation of p38 MAPK signaling. |
| WOS关键词 | CYTOPLASMIC VACUOLATION DEATH ; CANCER-CELLS ; HUMULUS-LUPULUS ; APOPTOSIS ; INDUCTION ; AUTOPHAGY ; STRESS |
| 资助项目 | National Natural Science Foundation of China[21372190] ; National Natural Science Foundation of China[31470426] ; Taishan Scholar Program of Shandong Province[tshw201502046] ; Yantai ShuangBai Scholar Program |
| WOS研究方向 | Oncology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000401003200054 |
| 出版者 | IMPACT JOURNALS LLC |
| 资助机构 | National Natural Science Foundation of China ; Taishan Scholar Program of Shandong Province ; Yantai ShuangBai Scholar Program |
| 源URL | [http://119.78.100.186/handle/113462/44746]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Li, Ji |
| 作者单位 | 1.Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Gansu, Peoples R China 2.Yantai Univ, Coll Life Sci, Ctr Mitochondrial & Hlth Aging, Yantai 264005, Shandong, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 4.Shihezi Univ, Sch Med, Shihezi 832000, Xinjiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mi, Xiangquan,Wang, Chunming,Sun, Chao,et al. Xanthohumol induces paraptosis of leukemia cells through p38 mitogen activated protein kinase signaling pathway[J]. ONCOTARGET,2017,8:31297-31304. |
| APA | Mi, Xiangquan.,Wang, Chunming.,Sun, Chao.,Chen, Xu.,Huo, Xiang.,...&Li, Ji.(2017).Xanthohumol induces paraptosis of leukemia cells through p38 mitogen activated protein kinase signaling pathway.ONCOTARGET,8,31297-31304. |
| MLA | Mi, Xiangquan,et al."Xanthohumol induces paraptosis of leukemia cells through p38 mitogen activated protein kinase signaling pathway".ONCOTARGET 8(2017):31297-31304. |
入库方式： OAI收割
来源：近代物理研究所
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