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Toxic effects of Fe-56 ion radiation on the zebrafish (Danio rerio) embryonic development

文献类型：期刊论文

作者Si, Jing1,2,3; Zhou, Rong1,2,3; Song, Jing'e4; Gan, Lu1,2,3; Zhou, Xin1,2,3; Di, Cuixia1,2,3; Liu, Yang1,2,3; Mao, Aihong1,2,3; Zhao, Qiuyue1,2,3; Wang, Yupei1,2,3
刊名AQUATIC TOXICOLOGY
出版日期2017-05-01
卷号186页码:87-95
关键词Fe-56 ion radiation Zebrafish embryos Developmental toxicity Apoptosis
ISSN号0166-445X
DOI10.1016/j.aquatox.2017.02.028
英文摘要All living organisms and ecosystems are permanently exposed to ionizing radiation. Of all the types of ionizing radiation, heavy ions such as Fe-56 have the potential to cause the most severe biological effects. We therefore examined the effects and potential mechanisms of iron ion irradiation on the induction of developmental toxicity and apoptosis in zebrafish embryos. Zebrafish embryos at 4h post-fertilization (hpf) were divided into five groups: a control group; and four groups irradiated with 0.5, 1, 2, and 4 Gy radiation, respectively. Mortality and teratogenesis were significantly increased, and spontaneous movement, heart rate, and swimming distance were decreased in the irradiated groups, accompanied by increased apoptosis. mRNA levels of genes involved in the apoptotic pathway, including p53, bax, bc1-2, and caspase3, were significantly affected by radiation exposure. Moreover, protein expression levels of P53 and Bcl-2 changed in accordance with the corresponding mRNA expression levels. In addition, we detected the protein expression levels of gamma-H2AX, which is a biomarker for radiation-induced DNA double-strand breaks, and found that gamma-H2AX protein levels were significantly increased in the irradiated groups. Overall, the results of this study improve our understanding of the mechanisms of iron ion radiation-induced developmental toxicity and apoptosis, potentially involving the induction of DNA damage and mitochondrial dysfunction. The findings of this study may aid future impact assessment of environmental radioactivity in fish. (C) 2017 Elsevier B.V. All rights reserved.
WOS关键词GAMMA-IRRADIATION ; OXIDATIVE STRESS ; DNA-REPAIR ; HEART-RATE ; MOLECULAR-MECHANISMS ; INDUCED APOPTOSIS ; GENE-EXPRESSION ; LET RADIATION ; CELL-DEATH ; LARVAE
资助项目Key Program of National Natural Science Foundation of China[U1432248] ; National Key Projects of Research and Development[2016YFC0904600] ; National Natural Science Foundation of China[11305226] ; National Natural Science Foundation of China[11605255] ; National Natural Science Foundation of China[116600530] ; Western Talent Program of Chinese Academy of Sciences[2013-165] ; Scientific Technology Research Projects of Lanzhou City[2015-3-75]
WOS研究方向Marine & Freshwater Biology ; Toxicology
语种英语
WOS记录号WOS:000401386100009
出版者ELSEVIER SCIENCE BV
资助机构Key Program of National Natural Science Foundation of China ; National Key Projects of Research and Development ; National Natural Science Foundation of China ; Western Talent Program of Chinese Academy of Sciences ; Scientific Technology Research Projects of Lanzhou City
源URL[http://119.78.100.186/handle/113462/44758]  
专题中国科学院近代物理研究所
通讯作者Zhang, Hong
作者单位1.Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou 730000, Peoples R China
2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China
3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou 730000, Gansu, Peoples R China
4.Lanzhou Univ, Hosp Stomatol, Lanzhou 730000, Peoples R China
5.Gansu Wuwei Inst Med Sci, Wuwei 733000, Peoples R China
推荐引用方式
GB/T 7714		 Si, Jing,Zhou, Rong,Song, Jing'e,et al. Toxic effects of Fe-56 ion radiation on the zebrafish (Danio rerio) embryonic development[J]. AQUATIC TOXICOLOGY,2017,186:87-95.
APA Si, Jing.,Zhou, Rong.,Song, Jing'e.,Gan, Lu.,Zhou, Xin.,...&Zhang, Hong.(2017).Toxic effects of Fe-56 ion radiation on the zebrafish (Danio rerio) embryonic development.AQUATIC TOXICOLOGY,186,87-95.
MLA Si, Jing,et al."Toxic effects of Fe-56 ion radiation on the zebrafish (Danio rerio) embryonic development".AQUATIC TOXICOLOGY 186(2017):87-95.

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来源：近代物理研究所

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