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Suppression of radiation-induced migration of non-small cell lung cancer through inhibition of Nrf2-Notch Axis

文献类型：期刊论文

作者Zhao, Qiuyue1,2,4,5; Mao, Aihong6; Guo, Ruoshui7; Zhang, Liping8; Yan, Jiawei1,2,4,5; Sun, Chao1,2,4; Tang, Jinzhou9; Ye, Yancheng3; Zhang, Yanshan3; Zhang, Hong1,2,3,4
刊名ONCOTARGET
出版日期2017-05-30
卷号8页码:36603-36613
关键词Nrf2 ionizing radiation Notch1 EMT NSCLC
ISSN号1949-2553
DOI10.18632/oncotarget.16622
英文摘要Nuclear factor E2 related factor 2 (Nrf2) is a transcription factor that is associated with tumor growth and resistance to radiation. The canonical Notch signaling pathway is also crucial for maintaining non-small cell lung cancer (NSCLC). Aberrant Nrf2 and Notch signaling has repeatedly been showed to facilitate metastasis of NSCLC. Here, we show that radiation induce Nrf2 and Notch1 expression in NSCLC. Knockdown of Nrf2 enhanced radiosensitivity of NSCLC and reduced epithelial-tomesenchymal transition. Importantly, we found that knockdown of Nrf2 dramatically decreased radiation-induced NSCLC invasion and significantly increased E-cadherin, but reduced N-cadherin and matrix metalloproteinase (MMP)-2/9 expression. We found that Notch1 knockdown also upregulated E-cadherin and suppressed N-cadherin expression. Nrf2 contributes to NSCLC cell metastatic properties and this inhibition correlated with reduced Notch1 expression. These results establish that Nrf2 and Notch1 downregulation synergistically inhibit radiation-induced migratory and invasive properties of NSCLC cells.
WOS关键词EPITHELIAL-MESENCHYMAL TRANSITION ; HEME OXYGENASE-1 EXPRESSION ; LYMPH-NODE METASTASIS ; TRANSCRIPTION FACTOR ; DOWN-REGULATION ; NOTCH PATHWAY ; NRF2 ; ACTIVATION ; INVASION ; GROWTH
资助项目Key program of National Natural Science Foundation of China[U1432248] ; Key program of National Natural Science Foundation of China[U1632270] ; Ministry of science and technology national key R D project[2016YFC0904600] ; National Natural Science Foundation of China[11665003] ; Scientific Technology Research Projects of Gansu Province[0702NKDA045] ; Scientific Technology Research Projects of Gansu Province[0801NKDA001] ; Scientific Technology Research Projects of Gansu Province[092NKDA034]
WOS研究方向Oncology ; Cell Biology
语种英语
WOS记录号WOS:000403230000093
出版者IMPACT JOURNALS LLC
资助机构Key program of National Natural Science Foundation of China ; Ministry of science and technology national key R D project ; National Natural Science Foundation of China ; Scientific Technology Research Projects of Gansu Province
源URL[http://119.78.100.186/handle/113462/44872]  
专题中国科学院近代物理研究所
通讯作者Zhang, Hong
作者单位1.Chinese Acad Sci, Inst Modern Phys, Dept Radiat Med, Lanzhou 730000, Peoples R China
2.Chinese Acad Sci, Key Lab Heavy Ion Radiat & Med, Lanzhou 730000, Peoples R China
3.Gansu Wuwei Inst Med Sci, Wuwei 733000, Gansu, Peoples R China
4.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou 730000, Gansu, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
6.Inst Gansu Med Sci Res, Lanzhou 730000, Peoples R China
7.South China Normal Univ, Guangzhou 510642, Guangdong, Peoples R China
8.Northwest Normal Univ, Lanzhou 730000, Peoples R China
9.Lan Zhou Univ, Lanzhou 730000, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Qiuyue,Mao, Aihong,Guo, Ruoshui,et al. Suppression of radiation-induced migration of non-small cell lung cancer through inhibition of Nrf2-Notch Axis[J]. ONCOTARGET,2017,8:36603-36613.
APA Zhao, Qiuyue.,Mao, Aihong.,Guo, Ruoshui.,Zhang, Liping.,Yan, Jiawei.,...&Zhang, Hong.(2017).Suppression of radiation-induced migration of non-small cell lung cancer through inhibition of Nrf2-Notch Axis.ONCOTARGET,8,36603-36613.
MLA Zhao, Qiuyue,et al."Suppression of radiation-induced migration of non-small cell lung cancer through inhibition of Nrf2-Notch Axis".ONCOTARGET 8(2017):36603-36613.

入库方式： OAI收割

来源：近代物理研究所

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