Contribution of caspase-independent pathway to apoptosis in malignant glioma induced by carbon ion beams
文献类型：期刊论文
| 作者 | Zhang, Luwei1,2,3; Yan, Jiawei1,2,4; Liu, Yang1,2,3 ; Zha, Qiuyue1,2,3; Di, Cuixia1,2,3; Chao, Sun1,2,3; Jie, Li1,5; Liu, Yuanyuan1,2,3; Zhang, Hong1,2,3
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| 刊名 | ONCOLOGY REPORTS
 |
| 出版日期 | 2017-05-01 |
| 卷号 | 37页码:2994-3000 |
| 关键词 | apoptosis CIB caspase-independent pathway apoptosis inducing factor PARP-1 glioma |
| ISSN号 | 1021-335X |
| DOI | 10.3892/or.2017.5529 |
| 英文摘要 | High linear energy transfer (LET) carbon ion beam (CIB) is becoming the best tool for external radiotherapy of inoperable tumors because of its greater cell killing than conventional low LET gamma or X-rays. In the present study, whether the caspase-independent pathway exerts the important contribution in CIB-induced cell apoptosis was explored. Herein we showed, despite the absence of caspase activity using a pan caspase inhibitor Z-VAD-FMK, that apoptosis induced by high LET CIB were clearly observed in the glioma cells. Simultaneously, the increased 8-OHdG level, PARP-1 activity and AIF translocation occurred in response to CIB irradiation. Moreover, it was distinctly higher in the nuclear translocation frequency along with PARP-1 activation when the caspase protease cascade was suppressed in the irradiated glioma cells. Nuclear colocalization between PARP-1 and AIF as well as a positive association of the PARP-1 mRNA expression with AIF translocation frequency indicated that PARP-1 activation controlled the translocation of AIF to the nucleus. Our findings strongly demonstrated that caspase-independent cell apoptosis provided a prominent compensation in the glioma cell death involving the PARP-1/AIF signaling pathway at 24 h after CIB exposure, and likely triggered by oxidative damage to DNA. The knowledge on the molecular mechanism of AIF-mediated cell death may be very useful for the improvement of the therapeutic efficacy of malignant gliomas with heavy charged particles. |
| WOS关键词 | POLYMERASE-1-DEPENDENT CELL-DEATH ; IONIZING-RADIATION ; FACTOR AIF ; AUTOPHAGY CONTRIBUTES ; CARCINOMA-CELLS ; CANCER-CELLS ; DNA-DAMAGE ; HELA-CELLS ; INHIBITION ; PARP-1 |
| 资助项目 | Key Program of National Natural Science Foundation of China[U1432248] ; Ministry of Science and Technology National Key RD Project[2016YFC0904602] ; National Natural Science Foundation of China[1120521] ; National Natural Science Foundation of China[11305224] ; National Natural Science Foundation of China[11575262] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000400629500052 |
| 出版者 | SPANDIDOS PUBL LTD |
| 资助机构 | Key Program of National Natural Science Foundation of China ; Ministry of Science and Technology National Key RD Project ; National Natural Science Foundation of China |
| 源URL | [http://119.78.100.186/handle/113462/45224]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, 509 Nanchang Rd, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 5.Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Luwei,Yan, Jiawei,Liu, Yang,et al. Contribution of caspase-independent pathway to apoptosis in malignant glioma induced by carbon ion beams[J]. ONCOLOGY REPORTS,2017,37:2994-3000. |
| APA | Zhang, Luwei.,Yan, Jiawei.,Liu, Yang.,Zha, Qiuyue.,Di, Cuixia.,...&Zhang, Hong.(2017).Contribution of caspase-independent pathway to apoptosis in malignant glioma induced by carbon ion beams.ONCOLOGY REPORTS,37,2994-3000. |
| MLA | Zhang, Luwei,et al."Contribution of caspase-independent pathway to apoptosis in malignant glioma induced by carbon ion beams".ONCOLOGY REPORTS 37(2017):2994-3000. |
入库方式： OAI收割
来源：近代物理研究所
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