NADPH Oxidase Activation Contributes to Heavy Ion Irradiation-Induced Cell Death
文献类型：期刊论文
| 作者 | Wang, Yupei1,2,3,4; Liu, Qing1,2,3,5; Zhao, Weiping1,2,3; Zhou, Xin1,2,3 ; Miao, Guoying1,2,3,6; Sun, Chao1,2,3; Zhang, Hong1,2,3,7
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| 刊名 | DOSE-RESPONSE
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| 出版日期 | 2017-03-24 |
| 卷号 | 15页码:6 |
| 关键词 | NADPH oxidase heavy ion irradiation ROS NOXs |
| ISSN号 | 1559-3258 |
| DOI | 10.1177/1559325817699697 |
| 英文摘要 | Increased oxidative stress plays an important role in heavy ion radiation-induced cell death. The mechanism involved in the generation of elevated reactive oxygen species (ROS) is not fully illustrated. Here we show that NADPH oxidase activation is closely related to heavy ion radiation-induced cell death via excessive ROS generation. Cell death and cellular ROS can be greatly reduced in irradiated cancer cells with the preincubation of diphenyleneiodium, an inhibitor of NADPH oxidase. Most of the NADPH oxidase (NOX) family proteins (NOX1, NOX2, NOX3, NOX4, and NOX5) showed increased expression after heavy ion irradiation. Meanwhile, the cytoplasmic subunit p47(phox) was translocated to the cell membrane and localized with NOX2 to form reactive NADPH oxidase. Our data suggest for the first time that ROS generation, as mediated by NADPH oxidase activation, could be an important contributor to heavy ion irradiation-induced cell death. |
| WOS关键词 | IONIZING-RADIATION ; ENDOTHELIAL-CELLS ; OXIDATIVE STRESS ; HEME OXYGENASE-1 ; STEM-CELLS ; INDUCTION ; DAMAGE ; KERATINOCYTES ; FIBROBLASTS ; INJURY |
| 资助项目 | Key Program of National Natural Science Foundation of China[U1432248] ; National Key projects of Research and Development[2016YFC0904600] ; National Natural Science Foundation of China[11505245] ; Western Talents Program of the Chinese Academy of Sciences[Y460040XB0] |
| WOS研究方向 | Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000400286900001 |
| 出版者 | SAGE PUBLICATIONS INC |
| 资助机构 | Key Program of National Natural Science Foundation of China ; National Key projects of Research and Development ; National Natural Science Foundation of China ; Western Talents Program of the Chinese Academy of Sciences |
| 源URL | [http://119.78.100.186/handle/113462/45227]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Gansu, Peoples R China 3.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China 5.Univ Shanghai Sci & Technol, Sch Med Instrument & Food Engn, Shanghai, Peoples R China 6.Gansu Prov Hosp, Lanzhou, Gansu, Peoples R China 7.Gansu Wuwei Inst Med Sci, Wuwei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yupei,Liu, Qing,Zhao, Weiping,et al. NADPH Oxidase Activation Contributes to Heavy Ion Irradiation-Induced Cell Death[J]. DOSE-RESPONSE,2017,15:6. |
| APA | Wang, Yupei.,Liu, Qing.,Zhao, Weiping.,Zhou, Xin.,Miao, Guoying.,...&Zhang, Hong.(2017).NADPH Oxidase Activation Contributes to Heavy Ion Irradiation-Induced Cell Death.DOSE-RESPONSE,15,6. |
| MLA | Wang, Yupei,et al."NADPH Oxidase Activation Contributes to Heavy Ion Irradiation-Induced Cell Death".DOSE-RESPONSE 15(2017):6. |
入库方式： OAI收割
来源：近代物理研究所
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