The Alternative Splicing of Caspase-9 and Its Application in Therapy of NSCLC
文献类型：期刊论文
| 作者 | Kuang Yan-Bei1,2,3,4; Li Ping1,2,3 ; Li Qiang1,2,3
|
| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2017-04-01 |
| 卷号 | 44页码:293-302 |
| 关键词 | caspase-9 alternative splicing caspase-9a/9b NSCLC chemotherapy sensitivity |
| ISSN号 | 1000-3282 |
| DOI | 10.16476/j.pibb.2016.0277 |
| 英文摘要 | Mounting evidence indicates the functional importance of alternative splice variations in cancer pathophysiology. The alternative splicing of caspase-9 plays an important role in non-small cell lung cancer (NSCLC). The splicing of caspase-9 gene generates two isoforms caspase-9a and caspase-9b, the ratio of caspase-9a/9b mRNA is pretty lower in a large proportion of human NSCLC tumors. A low caspase-9a/9b ratio, demanded for the tumorigenecity of NSCLC cells, is correlated with the sensitivity of NSCLC cells to anticancer therapy. Thus, the alternative splicing of caspase-9 suggests a novel and crucial distal mechanism in NSCLC and offers promise of a new target for the development of therapeutics in the defense against cancers. Therefore, this review is to summarize the alternative splicing of caspase-9 and its application in the therapy of NSCLC. |
| WOS关键词 | NF-KAPPA-B ; CELL LUNG-CANCER ; P53-DEPENDENT APOPTOSIS ; HNRNP L ; ACTIVATION ; TUMORIGENESIS ; INFLAMMATION ; INHIBITION ; EXPRESSION ; PATHWAY |
| 资助项目 | Key Project of National Natural Science Foundation of China[U1232207] ; National Natural Science Foundation of China[11305223] ; National Key Research and Development Program of the Ministry of Science and Technology of China[2016YFC0904700] ; National Key Technology Support Program of the Ministry of Science and Technology of China[2015BA101B11] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000399967800003 |
| 出版者 | CHINESE ACAD SCIENCES, INST BIOPHYSICS |
| 资助机构 | Key Project of National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of the Ministry of Science and Technology of China ; National Key Technology Support Program of the Ministry of Science and Technology of China |
| 源URL | [http://119.78.100.186/handle/113462/45285]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Li Ping; Li Qiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China 3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou 730000, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kuang Yan-Bei,Li Ping,Li Qiang. The Alternative Splicing of Caspase-9 and Its Application in Therapy of NSCLC[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2017,44:293-302. |
| APA | Kuang Yan-Bei,Li Ping,&Li Qiang.(2017).The Alternative Splicing of Caspase-9 and Its Application in Therapy of NSCLC.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,44,293-302. |
| MLA | Kuang Yan-Bei,et al."The Alternative Splicing of Caspase-9 and Its Application in Therapy of NSCLC".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 44(2017):293-302. |
入库方式： OAI收割
来源：近代物理研究所
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