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Serum microRNAs as Early Indicators for Estimation of Exposure Degree in Response to Ionizing Irradiation

文献类型：期刊论文

作者Wei, Wenjun1,2,3; He, Jinpeng1,2; Wang, Jufang1,2,4; Ding, Nan1,2; Wang, Bing1,2,3; Lin, Sulan1,2,3; Zhang, Xurui1,2,3; Hua, Junrui1,2; Li, He1,2,3; Hu, Burong1,2,4
刊名RADIATION RESEARCH
出版日期2017-09-01
卷号188页码:342-354
ISSN号0033-7587
DOI10.1667/RR14702.1
英文摘要Exposure to ionizing radiation from nuclear devices, spaceflights or terrorist attacks represents a major threat to human health and public security. After a radiological incident, noninvasive biomarkers that can facilitate rapid assessment of exposure risk in the early stages are urgently needed for optimal medical treatment. Serum microRNAs (miRNAs) are ideal biomarkers because they are stable in response to environmental changes, they are common among different species and are easily collected. Here, we performed miRNA PCR arrays to analyze miRNA expression profiles at 24 h postirradiation. Blood samples were collected from animals that received 0.5-2 Gy total-body carbon-ion irradiation. A specific signature with 12 radiosensitive miRNAs was selected for further validation. After exposure to 0.1-2 Gy of carbon-ion, iron-ion or X-ray radiations, five miRNAs that showed a significant response to these radiation types were selected for further observation of dose-and timedependent changes: miR-183-5p, miR-9-3p, miR-200b-5p, miR-342-3p and miR-574-5p. We developed a universal model using these five miRNAs to predict the degree of exposure to different radiation types with high sensitivity and specificity. In conclusion, we have identified a set of miRNAs that are quite sensitive to different radiation types in the early stages after exposure, demonstrating their potential use as effective indicators to predict the degree of exposure. (C) 2017 by Radiation Research Society
WOS关键词CELL LUNG-CANCER ; HEPATOCELLULAR-CARCINOMA ; CIRCULATING MICRORNA ; BIOMARKER ; CONSERVATION ; BIODOSIMETRY ; EXPRESSION ; IDENTIFICATION ; LYMPHOCYTES ; METASTASIS
资助项目Concept Research of Space Science Mission of Chinese Academy of Sciences[XDA15007803] ; International Science and Technology Cooperation Program of China[2015DFR30940] ; National Natural Sciences Foundation of China[31270895] ; National Natural Sciences Foundation of China[11405232] ; National Natural Sciences Foundation of China[31400723]
WOS研究方向Life Sciences & Biomedicine - Other Topics ; Biophysics ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000408424300009
出版者RADIATION RESEARCH SOC
资助机构Concept Research of Space Science Mission of Chinese Academy of Sciences ; International Science and Technology Cooperation Program of China ; National Natural Sciences Foundation of China
源URL[http://119.78.100.186/handle/113462/45588]  
专题中国科学院近代物理研究所
通讯作者Wang, Jufang
作者单位1.Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou 730000, Peoples R China
2.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou, Peoples R China
推荐引用方式
GB/T 7714		 Wei, Wenjun,He, Jinpeng,Wang, Jufang,et al. Serum microRNAs as Early Indicators for Estimation of Exposure Degree in Response to Ionizing Irradiation[J]. RADIATION RESEARCH,2017,188:342-354.
APA Wei, Wenjun.,He, Jinpeng.,Wang, Jufang.,Ding, Nan.,Wang, Bing.,...&Hu, Burong.(2017).Serum microRNAs as Early Indicators for Estimation of Exposure Degree in Response to Ionizing Irradiation.RADIATION RESEARCH,188,342-354.
MLA Wei, Wenjun,et al."Serum microRNAs as Early Indicators for Estimation of Exposure Degree in Response to Ionizing Irradiation".RADIATION RESEARCH 188(2017):342-354.

入库方式： OAI收割

来源：近代物理研究所

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