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Spot-scanning beam delivery with laterally-and longitudinally-mixed spot size pencil beams in heavy ion radiotherapy

文献类型：期刊论文

作者Yan, Yuan-Lin1,2,3,4; Liu, Xin-Guo1,2,3; Dai, Zhong-Ying1,2,3; Ma, Yuan-Yuan1,2,3,4; He, Peng-Bo1,2,3; Shen, Guo-Sheng1,2,3,4; Ji, Teng-Fei1,2,3,4; Zhang, Hui1,2,3,4; Li, Qiang1,2,3
刊名CHINESE PHYSICS C
出版日期2017-09-01
卷号41页码:10
关键词heavy ion radiotherapy spot-scanning beam spot size mini spread-out Bragg peak (mini-SOBP) mini ridge filter (mini-RF)
ISSN号1674-1137
DOI10.1088/1674-1137/41/9/098201
英文摘要The three-dimensional (3D) spot-scanning method is one of the most commonly used irradiation methods in charged particle beam radiotherapy. Generally, spot-scanning beam delivery utilizes the same size pencil beam to irradiate the tumor targets. Here we propose a spot-scanning beam delivery method with laterally- and longitudinally mixed size pencil beams for heavy ion radiotherapy. This uses pencil beams with a bigger spot size in the lateral direction and wider mini spread-out Bragg peak (mini-SOBP) to irradiate the inner part of a target volume, and pencil beams with a smaller spot size in the lateral direction and narrower mini-SOBP to irradiate the peripheral part of the target volume. Instead of being controlled by the accelerator, the lateral size of the pencil beam was adjusted by inserting Ta scatterers in the beam delivery line. The longitudinal size of the pencil beam (i.e. the width of the mini-SOBP) was adjusted by tilting mini ridge filters along the beam direction. The new spot-scanning beam delivery using carbon ions was investigated theoretically and compared with traditional spot-scanning beam delivery. Our results show that the new spot-scanning beam delivery has smaller lateral penumbra, steeper distal dose fall-off and the dose homogeneity (1-standard deviation/mean) in the target volume is better than 95%.
WOS关键词PROTON RADIOTHERAPY ; IRRADIATION SYSTEM ; PARTICLE THERAPY ; RIDGE FILTER ; OPTIMIZATION ; DESIGN ; EXTRACTION
资助项目Key Project of National Natural Science Foundation of China[U1232207] ; National Key Technology Support Program of the Ministry of Science and Technology of China[2015BAI01B11] ; National Key Research and Development Program of the Ministry of Science and Technology of China[2016YFC0904602] ; National Natural Science Foundation of China[11075191] ; National Natural Science Foundation of China[11205217] ; National Natural Science Foundation of China[11475231] ; National Natural Science Foundation of China[11505249]
WOS研究方向Physics
语种英语
WOS记录号WOS:000412407200019
出版者CHINESE PHYSICAL SOC
资助机构Key Project of National Natural Science Foundation of China ; National Key Technology Support Program of the Ministry of Science and Technology of China ; National Key Research and Development Program of the Ministry of Science and Technology of China ; National Natural Science Foundation of China
源URL[http://119.78.100.186/handle/113462/45840]  
专题中国科学院近代物理研究所
通讯作者Li, Qiang
作者单位1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China
2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China
3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou 730000, Gansu, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Yan, Yuan-Lin,Liu, Xin-Guo,Dai, Zhong-Ying,et al. Spot-scanning beam delivery with laterally-and longitudinally-mixed spot size pencil beams in heavy ion radiotherapy[J]. CHINESE PHYSICS C,2017,41:10.
APA Yan, Yuan-Lin.,Liu, Xin-Guo.,Dai, Zhong-Ying.,Ma, Yuan-Yuan.,He, Peng-Bo.,...&Li, Qiang.(2017).Spot-scanning beam delivery with laterally-and longitudinally-mixed spot size pencil beams in heavy ion radiotherapy.CHINESE PHYSICS C,41,10.
MLA Yan, Yuan-Lin,et al."Spot-scanning beam delivery with laterally-and longitudinally-mixed spot size pencil beams in heavy ion radiotherapy".CHINESE PHYSICS C 41(2017):10.

入库方式： OAI收割

来源：近代物理研究所

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