Integrated mRNAseq and microRNAseq data analysis for grade III gliomas
文献类型：期刊论文
| 作者 | Dai, Junqiang1; Bing, Zhitong2 ; Zhang, Yinian1; Li, Qiao1; Niu, Liang1; Liang, Wentao1; Yuan, Guoqiang3; Duan, Lei1; Yin, Hang1; Pan, Yawen1,3
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| 刊名 | MOLECULAR MEDICINE REPORTS
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| 出版日期 | 2017-11-01 |
| 卷号 | 16页码:7468-7478 |
| 关键词 | lower grade glioma microRNAseq mRNAseq weight gene co-expression network analysis the cancer genome atlas |
| ISSN号 | 1791-2997 |
| DOI | 10.3892/mmr.2017.7545 |
| 英文摘要 | The World Health Organization classification distinguishes four grades for gliomas. Grade III gliomas, which are brain malignant brain tumors with variable biological behavior and propensity, have been not widely investigated. The objective of the present study was to identify specific gene modules and valuable hubs associated with gliomagenesis and molecular signatures to assist in determining grade III glioma prognosis. mRNAseq and micro (mi)RNAseq data were used to construct a co-expression network of gliomas using weight gene co-expression network analysis, and revealed the prognostic molecular signature of grade III gliomas. The differently expressed miRNAs and mRNAs were identified. A total of 37 mRNAs and 10 miRNAs were identified, which were closely associated with the survival rates of patients with grade III glioma. To further understand the tumorigenesis, Cytoscape software was used to construct a network containing these differently expressed molecules. The result suggested that both the downregulated genes and upregulated genes are vital in the process of glioma deterioration, and certain genes are closely associated with clinical prognosis. |
| WOS关键词 | COEXPRESSION NETWORK ANALYSIS ; COLON-CANCER ; LUNG-CANCER ; PEPTIDASE 7 ; CELL-LINES ; EXPRESSION ; SURVIVAL ; ALPHA ; BRAIN ; PROGNOSIS |
| 资助项目 | Lanzhou Science and Technology Bureau[2013-3-27] ; Lanzhou Science and Technology Bureau[2015-3-86] ; Gansu Province Health Industry Research Project[GSWSKY-2015-58] ; National Natural Science Foundation of China[81501116] ; Lanzhou University Second Hospital[ynbskyjj2015-1-02] |
| WOS研究方向 | Oncology ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000414698900224 |
| 出版者 | SPANDIDOS PUBL LTD |
| 资助机构 | Lanzhou Science and Technology Bureau ; Gansu Province Health Industry Research Project ; National Natural Science Foundation of China ; Lanzhou University Second Hospital |
| 源URL | [http://119.78.100.186/handle/113462/46038]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Pan, Yawen |
| 作者单位 | 1.Lanzhou Univ, Hosp 2, Dept Neurosurg, 82 Cuiyingmen Rd, Lanzhou 730030, Gansu, Peoples R China 2.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 3.Lanzhou Univ, Hosp 2, Inst Neurol, Lanzhou 730030, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dai, Junqiang,Bing, Zhitong,Zhang, Yinian,et al. Integrated mRNAseq and microRNAseq data analysis for grade III gliomas[J]. MOLECULAR MEDICINE REPORTS,2017,16:7468-7478. |
| APA | Dai, Junqiang.,Bing, Zhitong.,Zhang, Yinian.,Li, Qiao.,Niu, Liang.,...&Pan, Yawen.(2017).Integrated mRNAseq and microRNAseq data analysis for grade III gliomas.MOLECULAR MEDICINE REPORTS,16,7468-7478. |
| MLA | Dai, Junqiang,et al."Integrated mRNAseq and microRNAseq data analysis for grade III gliomas".MOLECULAR MEDICINE REPORTS 16(2017):7468-7478. |
入库方式： OAI收割
来源：近代物理研究所
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