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Bone Loss Induced by Simulated Microgravity, Ionizing Radiation and/or Ultradian Rhythms in the Hindlimbs of Rats

文献类型：期刊论文

作者Zhang Ya Nan1,2; Shi Wen Gui1,2,3; Li He1,2,3; Hua Jun Rui1,2; Feng Xiu1,2; Wei Wen Jun1,2,3; Wang Ju Fang1,2; He Jin Peng1,2; Lei Su Wen4
刊名BIOMEDICAL AND ENVIRONMENTAL SCIENCES
出版日期2018-02-01
卷号31页码:126-135
关键词Bone loss Microgravity Radiation Ultradian rhythms
ISSN号0895-3988
DOI10.3967/bes2018.015
英文摘要Objective To better understand the pathological causes of bone loss in a space environment, including microgravity, ionizing radiation, and ultradian rhythms. Methods Sprague Dawley (SD) rats were randomly divided into a baseline group, a control group, a hindlimb suspension group, a radiation group, a ultradian rhythms group and a combined-three-factor group. After four weeks of hindlimb suspension followed by X-ray exposure and/or ultradian rhythms, biomechanical properties, bone mineral density, histological analysis, microstructure parameters, and bone turnover markers were detected to evaluate bone loss in hindlimbs of rats. Results Simulated microgravity or combined-three factors treatment led to a significant decrease in the biomechanical properties of bones, reduction in bone mineral density, and deterioration of trabecular parameters. Ionizing radiation exposure also showed adverse impact while ultradian rhythms had no significant effect on these outcomes. Decrease in the concentration of the turnover markers bone alkaline phosphatase (bALP), osteocalcin (OCN), and tartrate-resistant acid phosphatase-5b (TRAP-5b) in serum was in line with the changes in trabecular parameters. Conclusion Simulated microgravity is the main contributor of bone loss. Radiation also results in deleterious effects but ultradian rhythms has no significant effect. Combined-three factors treatment do not exacerbate bone loss when compared to simulated microgravity treatment alone.
WOS关键词LONG-DURATION SPACEFLIGHT ; CIRCADIAN-RHYTHMS ; TRABECULAR BONE ; MATURE MICE ; SHIFT WORK ; IN-VIVO ; MODEL ; IRRADIATION ; ASTRONAUTS ; METABOLISM
资助项目International Science & Technology Cooperation Program of China[2015DFR30940] ; Science and Technology Research Project of Gansu Province[145RTSA012] ; Science and Technology Research Project of Gansu Province[17JR5RA307]
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
语种英语
WOS记录号WOS:000427925500005
出版者CHINESE CENTER DISEASE CONTROL & PREVENTION
资助机构International Science & Technology Cooperation Program of China ; Science and Technology Research Project of Gansu Province
源URL[http://119.78.100.186/handle/113462/46352]  
专题中国科学院近代物理研究所
作者单位1.Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou 730000, Gansu, Peoples R China
2.Chinese Acad Sci, Inst Modern Phys, CAS Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Ctr Dis Control & Prevent, Off Hlth Stand, Beijing 102206, Peoples R China
推荐引用方式
GB/T 7714		 Zhang Ya Nan,Shi Wen Gui,Li He,et al. Bone Loss Induced by Simulated Microgravity, Ionizing Radiation and/or Ultradian Rhythms in the Hindlimbs of Rats[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2018,31:126-135.
APA Zhang Ya Nan.,Shi Wen Gui.,Li He.,Hua Jun Rui.,Feng Xiu.,...&Lei Su Wen.(2018).Bone Loss Induced by Simulated Microgravity, Ionizing Radiation and/or Ultradian Rhythms in the Hindlimbs of Rats.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,31,126-135.
MLA Zhang Ya Nan,et al."Bone Loss Induced by Simulated Microgravity, Ionizing Radiation and/or Ultradian Rhythms in the Hindlimbs of Rats".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 31(2018):126-135.

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来源：近代物理研究所

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